Abstract | BACKGROUND: Medial calcification in diabetes contributes to the arterial occlusive process occurring below the knee level. Adiponectin is an adipokine with atheroprotective properties and possible protective role against arterial calcification. The aim of the study was to investigate, in type 2 diabetes, the link between vascular expression and serum concentration of adiponectin and (1) peripheral arterial calcification and (2) lower limb occlusive arterial disease. METHODS: RESULTS: Peripheral arterial calcification score was higher in patients with the highest adiponectin concentration. In a multivariate logistic regression analysis, an increase of 1 µg/mL of adiponectin was associated with a 22% increase of arterial calcification (adjusted OR = 1.22; 95% CI 1.03-1.44; p = 0.02). Arterial occlusive score was also higher in patients with adiponectin concentration > median (2.8 ± 4.8 vs 4.2 ± 5.7, p = 0.034). Immunohistochemical analyses showed a strong and specific staining of adiponectin in smooth muscle cells in calcified arteries, with a more pronounced expression of adiponectin in early stages of medial calcification. CONCLUSIONS: Peripheral arterial calcification is positively associated with circulating adiponectin levels in patients with type 2 diabetes, but vascular adiponectin expression is already observed at early stages of calcification. Adiponectin secretion could be a compensatory mechanism against the calcification process.Trial registration DIACART NCT number: NCT02431234. Registered 30 April 2015.
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Authors | Carole E Aubert, Sophie Liabeuf, Chloé Amouyal, Salim Kemel, Frédérique Lajat-Kiss, Jean-Marc Lacorte, Marine Halbron, Aurélie Carlier, Joe-Elie Salem, Christian Funck-Brentano, Ljubica Perisic Matic, Anna Witasp, Peter Stenvinkel, Franck Phan, Ziad A Massy, Agnès Hartemann, Olivier Bourron |
Journal | Diabetology & metabolic syndrome
(Diabetol Metab Syndr)
Vol. 11
Pg. 32
( 2019)
ISSN: 1758-5996 [Print] England |
PMID | 31168327
(Publication Type: Journal Article)
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