The short-term effect analysis of intraoperative intraperitoneal perfusion chemotherapy with lobaplatin for colorectal cancer.

Abstract

PURPOSE:

To explore the safety and feasibility of intraoperative, intraperitoneal perfusion chemotherapy with lobaplatin for colorectal cancer (CRC).

METHODS:

From November 1, 2016 to January 15, 2017, a total of 100 patients with CRC in Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, who had undergone radical surgery, were randomized into two groups as follows: the lobaplatin group (50 patients) and the control group (50 patients). The time of recovery of postoperative intestinal functions, hematotoxicity, hepatic-renal toxicity, and postoperative complications were observed and analyzed, with the goal of exploring the safety and feasibility of the drug administration.

RESULTS:

The time to first gas exhaust in lobaplatin and the control group was 3.08 days and 3.20 days, respectively (p=0.392). The time of defecation in lobaplatin and the control group was 4.38 days and 4.50 days, respectively (p=0.524). There was no statistically significant difference between them in terms of the time of gas exhaust and defecation. One case with intra-abdominal hemorrhage, 1 case with anastomotic leakage, 3 cases with incision complication, 1 case with adhesive intestinal obstruction, and 1 case with pulmonary infection occurred in lobaplatin group compared to 1 case with anastomotic bleeding, 1 case with anastomotic leakage, 2 cases with incision complication, 2 cases with adhesive intestinal obstruction, 2 cases with pulmonary infection, and 1 case with lymphatic fistulas occurred in control group. There was no statistically significant difference between the groups in terms of the total incidence of postoperative complications (p=0.790). No statistically significant difference was observed between the groups in terms of leukocyte and platelet levels on the first, third, and fifth postoperative day. There was also no statistically significant difference in terms of platelet level 2 weeks after surgery. Both the lobaplatin and control group had 2 cases with postoperative abnormal hepatic-renal function. A total of 6 cases in the lobaplatin group and 7 cases in the control group developed gastrointestinal reactions, showing no statistically significant difference (p=0.766).

CONCLUSION:

Intraoperative intraperitoneal perfusion chemotherapy with lobaplatin showed no effect on short-term recovery in patients with CRC.

• Authors: Hai-Tao Zhou, Jun Jiang, Xu Guan, Hao Su, Jian Wei Liang, Wei Pei, Zheng Wang, Zheng Liu, Zheng Jiang, Qian Liu, Zhi Xiang Zhou, Wei Sen Jin, Xi Shan Wang
• Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology (J BUON) 2019 Mar-Apr Vol. 24 Issue 2 Pg. 442-448 ISSN: 2241-6293 [Electronic] Cyprus
• PMID: 31127989 (Publication Type: Journal Article)

Chemical References

• Cyclobutanes
• Organoplatinum Compounds
• lobaplatin

Topics

• Aged
• Anastomotic Leak (pathology)
• Chemotherapy, Cancer, Regional Perfusion (adverse effects)
• Colorectal Neoplasms (complications, drug therapy, pathology, surgery)
• Cyclobutanes (administration & dosage, adverse effects)
• Female
• Humans
• Intraoperative Period
• Male
• Middle Aged
• Organoplatinum Compounds (administration & dosage, adverse effects)
• Postoperative Complications (pathology)
• Postoperative Hemorrhage (pathology)