Abstract | BACKGROUND: METHODS: RESULTS: The BOB treatment increased TGF-β1 and VEGF-α expressions compared to Burn group. The histopathological analyses showed that epidermis and dermis layers injured due to burn. BOB treatment augmented the regeneration of these layers and increased fibroblast activity and keratinization which are play important role on the new blood vessels production. Also with the BOB treatment we showed wound contraction levels were higher than Burn and SS treatment. CONCLUSION: This study demonstrated that beeswax- olive oil-butter mixture impregnated bandage treatment in a second-degree burn rat model improved burn wound healing and encouraged skin renewal via modulating tissue TGF-β1 and VEGF-α.
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Authors | Yasin Bayir, Harun Un, Rustem Anil Ugan, Erol Akpinar, Elif Cadirci, Ilknur Calik, Zekai Halici |
Journal | Burns : journal of the International Society for Burn Injuries
(Burns)
Vol. 45
Issue 6
Pg. 1410-1417
(09 2019)
ISSN: 1879-1409 [Electronic] Netherlands |
PMID | 31126777
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier Ltd and ISBI. All rights reserved. |
Chemical References |
- Anti-Infective Agents, Local
- Olive Oil
- RNA, Messenger
- Tgfb1 protein, rat
- Transforming Growth Factor beta1
- Vascular Endothelial Growth Factor A
- Waxes
- vascular endothelial growth factor A, rat
- beeswax
- Butter
- Silver Sulfadiazine
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Topics |
- Animals
- Anti-Infective Agents, Local
(pharmacology)
- Bandages
- Burns
(genetics, metabolism, pathology, therapy)
- Butter
- Fibroblasts
(drug effects, pathology)
- Olive Oil
(pharmacology)
- RNA, Messenger
(drug effects, metabolism)
- Rats
- Silver Sulfadiazine
(pharmacology)
- Skin
(drug effects, metabolism, pathology)
- Transforming Growth Factor beta1
(drug effects, genetics)
- Vascular Endothelial Growth Factor A
(drug effects, genetics)
- Waxes
(pharmacology)
- Wound Healing
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