Urinary angiotensinogen in pediatric urinary tract infection.

Abstract

BACKGROUND:

Urinary tract infection (UTI) is one of the most common diseases in children, and urinary angiotensinogen (U-AGT) is a new biomarker gathering attention in many renal diseases. U-AGT reflects intrarenal renin-angiotensin system (RAS) activity. We conducted a study to measure U-AGT in children <4 months old with UTI.

METHODS:

All children <4 months old who came to Toshima Hospital with fever between January 2015 and December 2015 were included. Patients were divided into a UTI group and a non-UTI group, and U-AGT was measured.

RESULTS:

Median U-AGT was higher in patients with UTI compared with patients without UTI: (0.56 ng/dL, range, 0.025-2.753 ng/dL vs 0.13 ng/dL, range, 0.008-1.697 ng/dL, respectively; P < 0.05).

CONCLUSIONS:

U-AGT is elevated in UTI patients, and RAS activation may contribute to renal injury caused by UTI.

• Authors: Reina Mayumi, Yayoi Murano, Reina Yokota, Akihiro Nakao, Nao Miyazaki, Taichi Hara, Akira Mizutani, Kuniyoshi Hayashi, Yumiko Sakurai, Hiromichi Shoji, Tomoyuki Nakazawa, Toshiaki Shimizu
• Journal: Pediatrics international : official journal of the Japan Pediatric Society (Pediatr Int) Vol. 61 Issue 7 Pg. 712-714 (Jul 2019) ISSN: 1442-200X [Electronic] Australia
• PMID: 31120634 (Publication Type: Clinical Trial, Journal Article)
• Copyright: © 2019 Japan Pediatric Society.

Chemical References

• AGT protein, human
• Biomarkers
• Angiotensinogen

Topics

• Angiotensinogen (urine)
• Biomarkers (urine)
• Female
• Humans
• Infant
• Infant, Newborn
• Male
• Prospective Studies
• Urinary Tract Infections (diagnosis, urine)