Autologous hematopoietic stem cell transplantation as first-line consolidation therapy can improve the prognosis of diffuse large B-cell lymphoma with high expression of MYC protein.

Abstract

Myc-positive diffuse large B-cell lymphoma has lower curative efficacy and long-term survival than its negative counterpart, even when treated with R-CHOP regimen. The present study aims to determine whether the use of autologous hematopoietic stem cell transplantation as a consolidation therapy can improve the curative efficacy in this type of patients after achieving the best effect of chemotherapy for the first time. The data of 50 patients with Myc-positive diffuse large B-cell lymphoma were retrospectively analyzed. Autologous transplantation was performed for 23 patients, while transplantation was not performed for 27 patients. The clinicopathological features and survival conditions were compared. The 1-year and 3-year progression-free survival (PFS) rates were 66.7% ± 0.9% and 57.7% ± 1.0%, respectively, in the non transplantation group, and 100% and 82.1% ± 0.1%, respectively, in the transplantation group (P = .021). The 1-year overall survival (OS) rate for these two groups was 88.7% ± 0.6% vs 100%, respectively, while the 3-year OS rates for these two groups was 78.6% ± 0.1% vs 91.3% ± 0.1%, respectively (P = .176). Hematopoietic stem cell transplantation performed after chemotherapy is a risk factor for OS. Autologous hematopoietic stem cell transplantation as a consolidation therapy in the early stage can improve the prognosis of patients with Myc-positive diffuse large B-cell lymphoma.

• Authors: Kai Hu, Jin-Jie Gao, Qi-Hui Li, Lei Tian, Wei Wan, Wei Zhao, Ji-Jun Wang, Lin Fu
• Journal: The Kaohsiung journal of medical sciences (Kaohsiung J Med Sci) Vol. 35 Issue 7 Pg. 425-431 (Jul 2019) ISSN: 2410-8650 [Electronic] China (Republic : 1949- )
• PMID: 31050117 (Publication Type: Journal Article)
• Copyright: © 2019 The Authors. The Kaohsiung Journal of Medical Sciences published by John Wiley & Sons Australia on behalf of Kaohsiung Medical University.

Chemical References

• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Consolidation Chemotherapy (methods)
• Cyclophosphamide (therapeutic use)
• Doxorubicin (therapeutic use)
• Female
• Hematopoietic Stem Cell Transplantation
• Humans
• Lymphoma, Large B-Cell, Diffuse (mortality, pathology, therapy)
• Male
• Middle Aged
• Prednisone (therapeutic use)
• Prognosis
• Progression-Free Survival
• Retrospective Studies
• Transplantation, Autologous
• Vincristine (therapeutic use)