Abstract | PURPOSE: MATERIALS AND METHODS: This study consisted of a single-center, randomized controlled clinical trial in 138 patients who underwent PAE for BPH between July 2015 and December 2016. Patients were randomized to PAE using microspheres of different sizes: group A patients were treated with microspheres 100-300 μm, group B with 300-500 μm, and group C with 100-300 μm followed by 300-500 μm. All patients were evaluated before and at 1, 3, 6, 12, and 18 months after PAE. Baseline data were comparable across the 3 groups, using the following mean International Prostate Symptom Score/quality of life (IPSS/QoL); prostate volume (PV) scores, respectively: 23.0/4.14; 87.9 cm3 (group A); 23.0/4.09; 89.0 cm3 (group B); and 24.2/4.29; 81.0 cm3 (group C) (P > 0.05). RESULTS: Mean IPSS/QoL scores; PV after PAE were: 9.98/2.49; 65.1 cm3 (group A); 8.24/2.26; 63.1 cm3 (group B); and 10.1/2.69; 53.1 cm3 (group C) (P = 0.23; P = 0.39; P = 0.24). There were 26 clinical failures. The cumulative probabilities of clinical success at 18 months were 76.7% in group A, 82.6% in group B, and 83.3% in group C (P = 0.68). Nontarget embolization was prevented in 6 patients by coil embolization. All adverse events were mild and self-limited with rates of 86.0% in group A (37 of 43); 41.3% in group B (19 of 46); and 58.3% in group C (28 of 48) (P < 0.001). Dysuria was the most frequent adverse event (28 of 137 [20.4%]). CONCLUSIONS: PAE outcomes were not significantly different among microspheres of different sizes. The use of 100- to 300-μm microspheres was associated with an increased risk of minor adverse events.
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Authors | Daniel Torres, Nuno V Costa, João Pisco, Luis C Pinheiro, Antonio G Oliveira, Tiago Bilhim |
Journal | Journal of vascular and interventional radiology : JVIR
(J Vasc Interv Radiol)
Vol. 30
Issue 5
Pg. 638-644
(May 2019)
ISSN: 1535-7732 [Electronic] United States |
PMID | 31029381
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2019 SIR. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Acrylic Resins
- trisacryl gelatin microspheres
- Gelatin
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Topics |
- Acrylic Resins
(administration & dosage, adverse effects)
- Aged
- Arteries
- Embolization, Therapeutic
(adverse effects)
- Gelatin
(administration & dosage, adverse effects)
- Humans
- Injections, Intra-Arterial
- Lower Urinary Tract Symptoms
(diagnostic imaging, etiology, therapy)
- Male
- Middle Aged
- Particle Size
- Prospective Studies
- Prostate
(blood supply)
- Prostatic Hyperplasia
(complications, diagnostic imaging, therapy)
- Treatment Outcome
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