Controlled Release of Therapeutic Agents with Near-Infrared Laser for Synergistic Photochemotherapy toward Cervical Cancer.

Abstract

Different kinds of artificial drug delivery systems (DDS) have been widely exploited and utilized toward effective tumor therapy. Establishing a biocompatible DDS with a flexible release of the therapeutic agents has been a challenges and an impetus to the development of tumor diagnosis and therapy fields. Herein, the chemotherapeutic agents doxorubicin hydrochloride (DOX) and photosensitizer indocyanine green (ICG) were simultaneously packaged into the cavity of microvesicles (MVs) through the electroporation technique. With the aid of MVs-based DDS, the packaged therapeutic agents could be effectively delivered into the target tumor cells. The ambient temperature sharply increased because of controllable external near-infrared (NIR) laser irradiation, which induced the cracking of MVs-based DDS, directly accompanied by the dynamic and controllable release of DOX and ICG. Almost all the tumor cells could be killed by the synergistic effect of the released DOX and ICG. This research successfully established a smart DDS with NIR laser inducing controllable release of therapeutic agents for effective synergistic photochemotherapy toward cervical cancer.

• Authors: Lian Zhu, Cheng Wang, Dai-Wen Pang, Zhi-Ling Zhang
• Journal: Analytical chemistry (Anal Chem) Vol. 91 Issue 10 Pg. 6555-6560 (05 21 2019) ISSN: 1520-6882 [Electronic] United States
• PMID: 30994332 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• Antineoplastic Agents
• Photosensitizing Agents
• Doxorubicin
• Indocyanine Green

Topics

• Antibiotics, Antineoplastic (therapeutic use)
• Antineoplastic Agents
• Doxorubicin (therapeutic use)
• Female
• Humans
• Indocyanine Green (pharmacology)
• Lasers
• Photochemotherapy (methods)
• Photosensitizing Agents (therapeutic use)
• Uterine Cervical Neoplasms (therapy)