Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection.

Abstract

Stimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(N-vinylcaprolactam) nanogels against HIV-1 infection is presented for the first time. In particular, we have demonstrated that one of the synthesized poly(N-vinylcaprolactam) nanogels with initial concentration of 80 mg of vinylcaprolactam and 4% of crosslinking agent shows antiviral behavior against HIV-1 infection since this nanogel inhibits the viral replication in TZM.bl target cells.

• Authors: Micaela A Macchione, Carlos Guerrero-Beltrán, Anabella P Rosso, Esteban M Euti, Marisa Martinelli, Miriam C Strumia, Maria Ángeles Muñoz-Fernández
• Journal: Scientific reports (Sci Rep) Vol. 9 Issue 1 Pg. 5732 (04 05 2019) ISSN: 2045-2322 [Electronic] England
• PMID: 30952921 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Nanogels
• Polymers
• poly-N-vinylcaprolactam
• Caprolactam

Topics

• Antiviral Agents (pharmacology)
• Caprolactam (analogs & derivatives, pharmacology)
• Cell Survival (drug effects)
• HIV-1 (drug effects)
• Nanogels (administration & dosage)
• Polymers (pharmacology)
• Virus Replication (drug effects)