Prognostic significance of PAK family kinases in acute myeloid leukemia.

Abstract	Acute myeloid leukemia (AML) is a clonal and heterogeneous disease characterized by a myriad of genetic defects. Genetic abnormalities are powerful prognostic factors. P21-activated kinases (PAKs) are a kind of serine/threonine protein kinases, which is regulator of plenty of oncogenic signaling pathways. The clinical and prognostic value of PAKs in AML is unclear. A total of 155 AML patients with PAK expression data from The Cancer Genome Atlas database were enrolled in this study. Eighty-four patients underwent chemotherapy only, 71 also underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the chemotherapy-only group, high PAK3 and PAK7 expression were both bound up with poor EFS and OS (all P < 0.05). However, high PAK2 expressers had better EFS and OS (all P < 0.05). Multivariate analysis demonstrated that high PAK7 expression was an adverse independent prognostic factor in patients who received chemotherapy only. PAKs have no influence in EFS and OS in patients who underwent allo-HSCT. In conclusion, high PAK2 expression is a favorable prognostic factor, as to the high expression of PAK3 and PAK7, they are poor prognostic factors, and PAK7 has better prognostic value, but their prognostic effects can be offset by allo-HSCT.
Authors	Liang Quan, Zhiheng Cheng, Yifeng Dai, Yang Jiao, Jinlong Shi, Lin Fu
Journal	Cancer gene therapy (Cancer Gene Ther) Vol. 27 Issue 1-2 Pg. 30-37 (02 2020) ISSN: 1476-5500 [Electronic] England
PMID	30890765 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
Chemical References	Biomarkers, Tumor PAK5 protein, human PAK2 protein, human PAK3 protein, human p21-Activated Kinases
Topics	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols (therapeutic use) Biomarkers, Tumor (analysis, genetics) Bone Marrow (pathology) Disease-Free Survival Female Gene Expression Regulation, Leukemic Hematopoietic Stem Cell Transplantation Humans Kaplan-Meier Estimate Leukemia, Myeloid, Acute (genetics, mortality, pathology, therapy) Male Middle Aged Prognosis Protective Factors Risk Factors Transplantation, Homologous Young Adult p21-Activated Kinases (analysis, genetics)

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