Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population: A Multicenter Nationwide Study.

Abstract

BACKGROUND AND AIM:

Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population.

METHODS:

Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria.

RESULTS:

After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2% vs. 21.0%, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09-1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65 years old.

CONCLUSIONS:

H. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.

• Authors: Seon Hee Lim, Nayoung Kim, Jin Won Kwon, Sung Eun Kim, Gwang Ho Baik, Ju Yup Lee, Kyung Sik Park, Jeong Eun Shin, Hyun Joo Song, Dae-Seong Myung, Suck Chei Choi, Hyun Jin Kim, Joo Hyun Lim, Jeong Yoon Yim, Joo Sung Kim
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 64 Issue 8 Pg. 2219-2230 (08 2019) ISSN: 1573-2568 [Electronic] United States
• PMID: 30852768 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Comorbidity
• Cross-Sectional Studies
• Female
• Helicobacter Infections (diagnosis, epidemiology, microbiology)
• Helicobacter pylori (isolation & purification)
• Humans
• Male
• Metabolic Syndrome (diagnosis, epidemiology)
• Middle Aged
• Prevalence
• Prospective Studies
• Republic of Korea (epidemiology)
• Risk Factors
• Socioeconomic Factors
• Young Adult