Potential protective effects of red yeast rice in endothelial function against atherosclerotic cardiovascular disease.

Abstract

Atherosclerotic cardiovascular disease (ASCVD) is the deadliest disease in the world, with endothelial injury occurring throughout the course of the disease. Therefore, improvement in endothelial function is of essential importance in the prevention of ASCVD. Red yeast rice (RYR), a healthy traditional Chinese food, has a lipid modulation function and also plays a vital role in the improvement of endothelial reactivity and cardiovascular protection; thus, it is significant in the prevention and treatment of ASCVD. This article reviews the molecular mechanisms of RYR and its related products in the improvement of endothelial function in terms of endothelial reactivity, anti-apoptosis of endothelial progenitor cells, oxidative stress alleviation and anti-inflammation.

• Authors: Shu-Jun Feng, Zhi-Han Tang, Ying Wang, Xin-Ying Tang, Tao-Hua Li, Wei Tang, Ze-Min Kuang
• Journal: Chinese journal of natural medicines (Chin J Nat Med) Vol. 17 Issue 1 Pg. 50-58 (Jan 2019) ISSN: 1875-5364 [Electronic] China
• PMID: 30704624 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

Chemical References

• Biological Products
• Drugs, Chinese Herbal
• red yeast rice

Topics

• Apoptosis (drug effects)
• Atherosclerosis (pathology, physiopathology, prevention & control)
• Biological Products (chemistry, pharmacology, therapeutic use)
• Cardiovascular Diseases (pathology, physiopathology, prevention & control)
• Drugs, Chinese Herbal (chemistry, pharmacology, therapeutic use)
• Endothelium, Vascular (cytology, drug effects, physiology)
• Humans
• Inflammation (prevention & control)
• Lipid Metabolism (drug effects)
• Oxidative Stress (drug effects)