Abstract |
During the past decade, accumulating studies have been conducted on the mesoporous silica materials as the matrix of controlled drug-delivery, in which the complicated post-synthesis procedures are often involved with the molecular design to achieve the efficacy. In this study, a simplified drug delivery system of anti- cancer drug of doxorubicin (DOX) based on mesoporous SBA-15 functionalized with ferrocenecarboxylic acid (FCA) was constructed. Through a combination of physicochemical characterizations, the presence of FCA that was anchored inside the pore wall of amine groups grafted SBA-15 exhibits electron-accessible behavior without affecting the intactness of composite material. The pH-responsive release of drug molecules was achieved through the conjugation of DOX with FCA in the interior channels of mesoporous composites, which also favors the more coverage of DOX. Furthermore, the real-time cell analysis was performed to monitor the release of DOX from the mesopores and resulting cytotoxicity of cancer cell of A549 was evaluated, which results in a calculated IC50 of 43.8 μg/ml (24 h). The constructed mesoporous FCA-SBA-15 composite material provides an integrated nanoplatform to exert controlled-delivery of anti- cancer drug molecules.
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Authors | Zhihui Xu, Ling Cai, Huijun Jiang, Yujie Wen, Luming Peng, Yuan Wu, Jin Chen |
Journal | Analytica chimica acta
(Anal Chim Acta)
Vol. 1051
Pg. 138-146
(Mar 21 2019)
ISSN: 1873-4324 [Electronic] Netherlands |
PMID | 30661610
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier B.V. All rights reserved. |
Chemical References |
- Drug Carriers
- Ferrous Compounds
- Metallocenes
- SBA-15
- ferrocenecarboxylic acid
- Silicon Dioxide
- Doxorubicin
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Topics |
- A549 Cells
- Biological Transport
- Cell Survival
(drug effects)
- Doxorubicin
(chemistry, pharmacology)
- Drug Carriers
(chemistry, metabolism)
- Drug Liberation
- Drug Screening Assays, Antitumor
- Ferrous Compounds
(chemistry)
- HeLa Cells
- Humans
- Hydrogen-Ion Concentration
- Intracellular Space
(metabolism)
- Metallocenes
- Porosity
- Silicon Dioxide
(chemistry)
- Time Factors
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