[Use of blinatumomab in children acute lymphoblastic leukemia in the Grand Ouest interregion: A chance for all].

Abstract

INTRODUCTION:

Relapsed/refractory acute lymphoblastic leukemia (ALL) in children has a pejorative prognosis and justifies to be treated by hematopoietic stem cell transplantation (HSCT). A minimal residual disease (MRD) before transplantation is a major part of prognosis. Blinatumomab, a bispecific antibody CD19+/CD3+, allowed to achieve a cytologic and molecular complete remission in adults with refractory B-precursor ALL. This retrospective study analyses results from a pediatric cohort treated by blinatumomab thanks to an interregional structuring consortium.

PATIENTS AND METHODS:

Patients between 0 and 23 years old, from the 7 centers of the french "Grand Ouest" interregional network, treated by blinatumomab for a relapsed or refractory ALL, from January 2015 to January 2018, were included. The efficiency of blinatumomab was assessed in terms of complete remission, minimal residual disease, overall survival, and tolerability of treatment.

RESULTS:

Thirteen of 18 patients achieved a complete remission, with negative minimal residual disease for ten of them. Fourteen patients proceeded to stem cell transplantation,. Eight out of 14 patients obtained long term remission after HSCT. As far as tolerance is concerned, no serious adverse event, neurological or psychiatric disorder, was observed.

CONCLUSION:

Thanks to an interregional network collaboration, all children with high risk ALL coming from the western french interregion could be treated by blinatumomab. Blinatumomab offered good hematological conditions to undergo HSCT with a good tolerability.

• Authors: Margaux Camuset, Audrey Grain, Fleur Lorton, Odile Minckes, Anne Jourdain, Frédéric Millot, Isabelle Pellier, Virginie Gandemer, Fanny Rialland Battisti
• Journal: Bulletin du cancer (Bull Cancer) Vol. 106 Issue 3 Pg. 206-215 (Mar 2019) ISSN: 1769-6917 [Electronic] France
• Vernacular Title: Expérience du blinatumomab dans les leucémies aiguës lymphoblastiques de l’enfant et de l’adolescent dans l’interrégion Grand Ouest : une chance pour tous.
• PMID: 30638898 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

Chemical References

• Antibodies, Bispecific
• Antineoplastic Agents
• blinatumomab

Topics

• Adolescent
• Antibodies, Bispecific (therapeutic use)
• Antineoplastic Agents (therapeutic use)
• Child
• Child, Preschool
• Female
• France
• Hematopoietic Stem Cell Transplantation (adverse effects, statistics & numerical data)
• Humans
• Infant
• Male
• Neoplasm, Residual
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy, mortality, surgery)
• Prognosis
• Recurrence
• Remission Induction
• Retrospective Studies
• Young Adult