Abstract | BACKGROUND: METHODS: Patients with locally advanced NPC treated at a tertiary hospital in China prior to curative chemoradiotherapy were eligible for this exploratory randomized study. Patients were assigned to either the intervention or the control group based on a computer-generated randomization sequence. The intervention group commenced ONS at the start of chemoradiotherapy. Outcomes included body weight, BMI, nutritional status and QOL. RESULTS: From June 2015 to June 2016, 50 patients with NPC were randomized to intervention and 50 to the control group. Patients in the ONS group had a higher body weight at the end of chemoradiotherapy (59.11 kg vs 58.14 kg, p = 0.036). A higher BMI and prealbumin were observed in the ONS group (p = 0.021 and p = 0.048, respectively). No other differences were found for nutritional status, QOL or clinical outcomes. CONCLUSION: ONS had beneficial outcomes in terms of reducing weight loss, minimizing BMI decrease and increasing protein intake in loco-regionally advanced NPC patients during chemoradiotherapy.
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Authors | Wen Jiang, Huiping Ding, Weiwei Li, Yiqun Ling, Chaosu Hu, Chunying Shen |
Journal | Nutrition and cancer
(Nutr Cancer)
2018 Nov-Dec
Vol. 70
Issue 8
Pg. 1299-1307
ISSN: 1532-7914 [Electronic] United States |
PMID | 30633580
(Publication Type: Journal Article, Randomized Controlled Trial, Video-Audio Media)
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Topics |
- Administration, Oral
- Adult
- Body Mass Index
- Chemoradiotherapy
(adverse effects)
- Dietary Supplements
- Female
- Humans
- Male
- Middle Aged
- Nasopharyngeal Neoplasms
(pathology, therapy)
- Nutrition Therapy
(methods)
- Nutritional Status
- Prospective Studies
- Quality of Life
- Weight Loss
(drug effects)
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