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The Path to Group A Streptococcus Vaccines: World Health Organization Research and Development Technology Roadmap and Preferred Product Characteristics.

Abstract
Group A Streptococcus (GAS) infections result in a considerable underappreciated burden of acute and chronic disease globally. A 2018 World Health Assembly resolution calls for better control and prevention. Providing guidance on global health research needs is an important World Health Organization (WHO) activity, influencing prioritization of investments. Here, the role, status, and directions in GAS vaccines research are discussed. WHO preferred product characteristics and a research and development technology roadmap, briefly presented, offer an actionable framework for vaccine development to regulatory and policy decision making, availability, and use. GAS vaccines should be considered for global prevention of the range of clinical manifestations and associated antibiotic use. Impediments related to antigen diversity, safety concerns, and the difficulty to establish vaccine efficacy against rheumatic heart disease are discussed. Demonstration of vaccine efficacy against pharyngitis and skin infections constitutes a key near-term strategic goal. Investments and collaborative partnerships to diversify and advance vaccine candidates are needed.
AuthorsJohan Vekemans, Fernando Gouvea-Reis, Jerome H Kim, Jean-Louis Excler, Pierre R Smeesters, Katherine L O'Brien, Chris A Van Beneden, Andrew C Steer, Jonathan R Carapetis, David C Kaslow
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 69 Issue 5 Pg. 877-883 (08 16 2019) ISSN: 1537-6591 [Electronic] United States
PMID30624673 (Publication Type: Journal Article)
Copyright© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
Chemical References
  • Streptococcal Vaccines
Topics
  • Biomedical Research
  • Cost of Illness
  • Global Health
  • Humans
  • Policy Making
  • Streptococcal Infections (prevention & control)
  • Streptococcal Vaccines
  • Streptococcus pyogenes (immunology)
  • World Health Organization

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