Abstract | BACKGROUND AND AIM: MATERIALS AND METHODS: Forty-six gallstone patients (age 55 ± 2 years; 15M, 31F) and 24 cholecystectomized patients (age 57 ± 2 years; 6M, 18F) (no difference in type and volume of gallstones between the two groups) were compared against a group of 65 healthy controls (age 51 ± 2 years; 30M, 35F). Dyspepsia occurring in the prior months was assessed by a questionnaire, gastric and gallbladder emptying by functional ultrasonography and orocecal transit time by a hydrogen breath test using a lactulose-enriched standard liquid meal. RESULTS:
Gallstone patients had significantly greater dyspepsia, fasting and residual gallbladder volumes, and slower gallbladder emptying, gastric emptying and small intestinal transit time than controls. In cholecystectomized patients, gastric emptying further delayed, compared to gallstone patients and controls. CONCLUSION:
Gallstone patients with the gallbladder "in situ" or after a cholecystectomy display dyspeptic symptoms. Symptoms are associated with multiple gastrointestinal motility defects involving the gallbladder, stomach and small intestine. After cholecystectomy, gastric emptying worsens.
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Authors | Agostino Di Ciaula, Emilio Molina-Molina, Leonilde Bonfrate, David Q-H Wang, Dan L Dumitrascu, Piero Portincasa |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 49
Issue 3
Pg. e13066
(Mar 2019)
ISSN: 1365-2362 [Electronic] England |
PMID | 30592298
(Publication Type: Journal Article)
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Copyright | © 2018 Stichting European Society for Clinical Investigation Journal Foundation. |
Topics |
- Cholecystectomy
- Dyspepsia
(etiology, physiopathology)
- Female
- Gallbladder Emptying
(physiology)
- Gallstones
(complications, physiopathology, surgery)
- Gastric Emptying
(physiology)
- Gastrointestinal Transit
(physiology)
- Humans
- Male
- Middle Aged
- Postoperative Complications
(etiology)
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