Lactulose (Duphalac)

A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887)

Also Known As:

Networked: 867 relevant articles (102 outcomes, 139 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Sharma, Praveen: 13 articles (09/2013 - 06/2008)
2.	Pimentel, Mark: 13 articles (07/2011 - 12/2002)
3.	Sharma, Barjesh Chander: 10 articles (08/2015 - 09/2009)
4.	Sarin, Shiv Kumar: 7 articles (08/2012 - 06/2008)
5.	Kong, Yuthana: 7 articles (04/2007 - 12/2002)
6.	Rockey, Don C: 6 articles (05/2015 - 05/2011)
7.	Rahimi, Robert S: 6 articles (05/2015 - 05/2011)
8.	Park, Sandy: 6 articles (04/2007 - 01/2003)
9.	Melichar, Bohuslav: 5 articles (11/2014 - 01/2007)
10.	Gibson, Peter R: 5 articles (05/2014 - 12/2007)

Related Diseases

1.	Hepatic Encephalopathy 10/01/2012 - "Compared to placebo or lactulose, treatment with probiotics or synbiotics significantly improved hepatic encephalopathy (RR = 1.40, 95% CI = 1.05-1.86, I(2)  = 5%). " 01/01/2011 - "A possible case of minimal hepatic encephalopathy treated successfully with lactulose." 01/01/1994 - "In contrast, the time required for a lactulose load to reach the cecum was significantly greater in the patients with hepatic encephalopathy (p < 0.01) and increased as a function of the hepatic encephalopathy grade.(ABSTRACT TRUNCATED AT 250 WORDS)" 05/01/2014 - "Lactulose therapy was effective for cirrhotic patients as primary prophylaxis to prevent overt hepatic encephalopathy (OHE) episodes. " 07/01/2012 - "Lactulose is effective in secondary prophylaxis of hepatic encephalopathy (HE). "
2.	Constipation 10/01/2007 - "The clinical complete remission rate of constipation in the forlax and lactulose groups was 70% and 40% respectively (P < 0.05) by week 1 of treatment, and that was 72% and 41% respectively (P < 0.05) by week 2 of treatment. " 10/01/2007 - "The therapeutic effects, including bowel movement frequency, stool consistency, clinical complete remission rate of constipation and abdominal symptoms, and the safety of forlax and lactulose were evaluated at 1 and 2 weeks of treatment. " 07/01/2006 - "It is significantly more effective than lactulose as maintenance therapy, both in efficacy in treating constipation and efficacy in preventing the recurrence of faecal impaction." 09/01/1988 - "The observed effects indicate that lactulose yoghurt may be beneficial in the treatment or chronic constipation using dietary methods." 01/01/2014 - "PEG 4000 has superior efficacy to lactulose for the treatment of chronic constipation in young children and is well tolerated. "
3.	Fibrosis (Cirrhosis) 12/01/2014 - "Compared with lactulose alone, Chinese herbal medicine formula Jieduhuayu granules has higher efficacy of improving cognitive and neurophysiological functions in patients with cirrhosis who have MHE, and the two of them together show synergistic action. " 07/01/2012 - "Lactulose and probiotics are effective for secondary prophylaxis of HE in patients with cirrhosis." 06/01/2011 - "Lactulose is effective in prevention of HE in patients with cirrhosis and acute variceal bleed." 09/01/2009 - "Lactulose is effective for prevention of recurrence of HE in patients with cirrhosis." 02/01/2015 - "Lactulose excretion alone was increased in children with PHT as compared with healthy children (median %: 0.03, 0.02, and 0.01 for cirrhosis, extrahepatic portal venous obstruction, and controls, respectively [P < 0.01]) signifying increased paracellular permeability in PHT. "
4.	Colitis 04/01/1995 - "Enteral administration of lactulose to rats with colitis was associated with a significant reduction in the systemic concentration of endotoxin (median (range) 5.4 (0-19.9) versus 23.7 (0-145.0) pg/ml in colitic rats treated with water; 4.6 (0-10.8) pg/ml in healthy animals). " 03/01/2005 - "The present study describes the preventive antiinflammatory activity of lactulose in the trinitrobenzenesulphonic acid (TNBS) model of rat colitis. " 05/14/2014 - "In conclusion, OsLu showed a better anti-inflammatory profile than lactulose in this model of experimental colitis. " 06/01/2013 - "Lactulose can prevent the development of DSS-induced colitis and alleviate oxidative stress in the colon, as measured by MDA and MPO, probably by increasing endogenous H2 production." 03/01/2005 - "One group of colitic rats received lactulose, which was incorporated in the drinking water (2.5% wt/vol) for 2 weeks before TNBS instillation, and colonic damage was evaluated 1 week after colitis induction. "
5.	Crohn Disease (Crohn's Disease) 12/01/2003 - "We performed the lactulose breath test in 145 consecutive patients affected by Crohn's disease. " 10/01/1989 - "Lactulose absorption by patients with Crohn's disease was 0.41% +/- 0.07% (mean +/- SE), whereas that of their relatives and unrelated controls was 0.28% +/- 0.03% and 0.26% +/- 0.03%, respectively. " 10/01/1989 - "Patients with Crohn's disease had increased lactulose permeability when compared with relatives or controls. " 12/01/2008 - "Six-hour urinary lactulose excretion in Crohn's disease patients was significantly higher than in both celiac disease patients (0.42 vs 0.15%) and healthy controls (0.42 vs 0.07%). " 06/01/1995 - "The lactulose tolerance tests were performed 22 times in 14 patients with Crohn's disease (CD), 19 times in 12 patients with ulcerative colitis (UC), and 12 times in 12 healthy controls. "

Related Drugs and Biologics

1.	Mannitol (Osmitrol)
2.	lactitol
3.	Polyethylene Glycols (Polyethylene Glycol)
4.	Neomycin
5.	Sorbitol (Yal)
6.	rifaximin (L 105)
7.	Hydrogen
8.	Rhamnose
9.	Glucose (Dextrose)
10.	Ammonia

Related Therapies and Procedures

1.	Oral Administration
2.	Enema (Enemas)
3.	Surgical Portasystemic Shunt (Portosystemic Shunt)
4.	Long-Term Care
5.	Antibiotic Prophylaxis