Abstract | PURPOSE: METHODS: This retrospective and longitudinal study included graft versus host disease patients with ocular disorders. The resolution of corneal ulcers (area and density staining) was evaluated as primary outcome. Best corrected visual acuity, intraocular pressure, tear film breakup time, Schirmer test, ocular surface disease index, and visual analog score were evaluated as secondary outcomes. All variables were analyzed before and after plasma rich in growth factors treatment. The safety of plasma rich in growth factors treatment was also assessed. RESULTS: Twelve patients (23 eyes) with ocular graft versus host disease were evaluated. Statistically significant improvement in the area (75.7%) and density (73.3%) of the corneal staining, in best corrected visual acuity (74.7%), in ocular surface disease index scale (75.4%), visual analog score frequency (81.4%) and visual analog score severity (81.9%), and an increase of 3.8 s in tear film breakup time and 6 mm in Schirmer test was observed after plasma rich in growth factors treatment (p < 0.001). Some potential modifiers of the therapeutic effect were identified. All patients achieved corneal stability without perforation risk. No adverse events associated with the plasma rich in growth factors were observed. CONCLUSION:
|
Authors | Ronald M Sanchez-Avila, Jesus Merayo-Lloves, Francisco Muruzabal, Gorka Orive, Eduardo Anitua |
Journal | European journal of ophthalmology
(Eur J Ophthalmol)
Vol. 30
Issue 1
Pg. 94-103
(Jan 2020)
ISSN: 1724-6016 [Electronic] United States |
PMID | 30585084
(Publication Type: Journal Article, Observational Study)
|
Chemical References |
- Intercellular Signaling Peptides and Proteins
- Ophthalmic Solutions
|
Topics |
- Adult
- Aged
- Dry Eye Syndromes
(etiology, metabolism, therapy)
- Female
- Follow-Up Studies
- Graft vs Host Disease
(complications, therapy)
- Humans
- Intercellular Signaling Peptides and Proteins
(pharmacology)
- Male
- Middle Aged
- Ophthalmic Solutions
(therapeutic use)
- Platelet-Rich Plasma
- Retrospective Studies
- Tears
(metabolism)
|