Abstract | BACKGROUND: Diabetic chronic kidney disease (CKD) has become the main cause of death in diabetic patients, but its pathogenesis has not yet been clear. OBJECTIVE: To investigate the effects of reduced glutathione (GSH) on oxidative stress (OS), angiogenesis factors and lymphocyte subsets in diabetic CKD patients. METHODS: RESULTS:
After treatment, the indexes of OS and angiogenesis and the percentage of CD3- CD19+ B cells were obviously decreased, and the percentages of T cell subsets and natural killer (NK) cell subsets were markedly increased in the treatment group compared with the control group. AOPP was positively correlated with angiogenesis indexes, MDA and CD3- CD19+ B cells, and negatively correlated with SOD and other lymphocyte subsets. SOD was inversely associated with angiogenesis indexes and MDA, and positively associated with lymphocyte subsets. Moreover, MDA had a positive correlation with angiogenesis indexes, B and T cell subsets, and a negative correlation with NK cell subsets. AOPP, MDA, SOD, VEGF, CD3+ T cells, CD3+ CD8+ T cells, CD3- CDl6+ CD56+ NK cells, and CD3- CDl6+ CD56+ NK T cells were the risk factors of diabetic CKD. CONCLUSION: GSH could inhibit OS and abnormal angiogenesis, and improve cellular immune response in CKD patients.
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Authors | Man-Hua Zuo, Jun Tang, Miao-Miao Xiang, Qing Long, Jian-Ping Dai, Guo-Dan Yu, Hua-Guo Zhang, Hui Hu |
Journal | Journal of cellular biochemistry
(J Cell Biochem)
Vol. 120
Issue 5
Pg. 8483-8491
(05 2019)
ISSN: 1097-4644 [Electronic] United States |
PMID | 30556156
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2018 Wiley Periodicals, Inc. |
Chemical References |
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Topics |
- Case-Control Studies
- Diabetic Nephropathies
(drug therapy, pathology)
- Female
- Glutathione
(therapeutic use)
- Humans
- Lymphocyte Subsets
(metabolism)
- Male
- Middle Aged
- Neovascularization, Physiologic
- Oxidative Stress
- Renal Insufficiency, Chronic
(drug therapy, pathology)
- Risk Factors
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