Usefulness of baseline statin therapy in non-obstructive coronary artery disease by coronary computed tomographic angiography: From the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) study.
Abstract | BACKGROUND: The extent to which the presence and extent of subclinical atherosclerosis by coronary computed tomography angiography influences a potential mortality benefit of statin is unknown. We evaluated the relationship between statin therapy, mortality, and subclinical atherosclerosis. METHODS: RESULTS: 1.2% of patients experienced all-cause mortality. Patients not on baseline statin therapy had a stepwise increased risk of all-cause mortality by CAC (relative to CAC = 0; CAC 1-99: hazard ratio [HR] 1.65, CAC 100-299: HR 2.19, and CAC≥300: HR 2.98) or SIS (relative to SIS = 0; SIS 1: HR 1.62, SIS 2-3: 2.48 and SIS≥4: 2.95). Conversely, in patients on baseline statin therapy, there was no significant increase in mortality risk with increasing CAC (p value for interaction = 0.049) or SIS (p value for interaction = 0.007). The incidence of MACE was 2.1%. Similar to the all-cause mortality, the risk of MACE was increased with CAC or SIS strata in patient not on baseline statin therapy. However, this relation was not observed in patient on baseline statin therapy. CONCLUSION:
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Authors | Yun-Kyeong Cho, Chang-Wook Nam, Bon-Kwon Koo, Joshua Schulman-Marcus, Bríain Ó Hartaigh, Heidi Gransar, Yao Lu, Stephan Achenbach, Mouaz Al-Mallah, Daniele Andreini, Jeroen J Bax, Matthew J Budoff, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J W Chow, Ricardo C Cury, Augustin Delago, Gudrun Feuchtner, Martin Hadamitzky, Jörg Hausleiter, Philipp A Kaufmann, Yong-Jin Kim, Jonathon Leipsic, Erica Maffei, Hugo Marques, Gianluca Pontone, Gilbert L Raff, Ronen Rubinshtein, Leslee J Shaw, Todd C Villines, Daniel S Berman, Erica C Jones, Jessica M Peña, Fay Y Lin, James K Min |
Journal | PloS one
(PLoS One)
Vol. 13
Issue 12
Pg. e0207194
( 2018)
ISSN: 1932-6203 [Electronic] United States |
PMID | 30540755
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Topics |
- Aged
- Computed Tomography Angiography
- Coronary Artery Disease
(diagnosis, drug therapy, mortality)
- Coronary Vessels
(diagnostic imaging)
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Registries
- Treatment Outcome
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