A prospective longitudinal evaluation of cognition and depression in postoperative patients with high-grade glioma following radiotherapy and chemotherapy.

Abstract

AIM OF STUDY:

The survival rate in high-grade glioma (HGG) patients receiving a combined regimen of radiotherapy (RT) and temozolomide after tumor resection was increased. However, cognitive deficits and depression after the treatments challenge the treatments. The aim of this study was to evaluate the cognition and depression in postoperative patients with HGG following RT and chemotherapy.

MATERIALS AND METHODS:

Six-five eligible patients were included in the study. Cognition and depression were examined at baseline (after surgery before RT), every 3 months during follow-up using mini-mental state examination and Zung Self-Rating Depression Scale (SDS), respectively.

RESULTS:

Our results showed that cognition was not significantly affected after treatments (F = 1.19, P = 0.32). However, significant differences between baseline and follow-ups were found regarding SDS scores (F = 3.26, P =0.0.01). SDS score at the 3rd month was significantly higher than that at baseline (t = -3.16, P = 0.002).

CONCLUSION:

This prospective study showed that although cognition was not significantly affected, the treatment caused depression, particularly at the 3rd month. These data implicated that interventions should be designed to deal with depression in the 3rd month.

• Authors: Qiang Wang, Fei Qi, Xiaopeng Song, Jie Di, Licheng Zhang, Yuan Zhou, Xin Lu, Jin Chang, Yonghua Yu
• Journal: Journal of cancer research and therapeutics (J Cancer Res Ther) Vol. 14 Issue Supplement Pg. S1048-S1051 (Dec 2018) ISSN: 1998-4138 [Electronic] India
• PMID: 30539844 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Alkylating
• Temozolomide

Topics

• Adult
• Antineoplastic Agents, Alkylating (adverse effects)
• Brain (pathology, surgery)
• Brain Neoplasms (mortality, pathology, psychology, therapy)
• Chemoradiotherapy, Adjuvant (adverse effects, methods)
• Cognitive Dysfunction (chemically induced, diagnosis, psychology)
• Depression (chemically induced, diagnosis, psychology)
• Female
• Glioma (mortality, pathology, psychology, therapy)
• Humans
• Karnofsky Performance Status
• Longitudinal Studies
• Male
• Patient Health Questionnaire
• Postoperative Period
• Prospective Studies
• Quality of Life
• Survival Rate
• Temozolomide (adverse effects)
• Young Adult