Abstract | INTRODUCTION: The prevalence of type 2 diabetes (T2D) is increasing worldwide. Recent studies have suggested that environmental factors, such as exposure to brominated flame retardants (BFRs), could play a role in the epidemic of T2D. The aim of this study was to analyze the association between the dietary exposure to BFRs ( Hexabromocyclododecane (HBCD) and Polybromodiphenylether ( PBDE)) and T2D risk in the E3N prospective cohort of French women. RESEARCH DESIGN AND METHODS: Overall, 71,415 women followed for 19 years were included in the study. We performed Cox regression models to analyze the association between dietary exposure to BFRs and T2D risk. RESULTS: Overall 71,415 women were included and 3667 (5.13%) developed a T2D during follow-up. The mean dietary exposure to HBCD and to PBDE was 0.22 ng/kg body weight (BW)/day and 1.21 ng/kg bw/day, respectively. There was a positive linear association between dietary exposure to HBCD and T2D risk starting from the 2nd quintile group (HR: 1.18; 95% CI: 1.06-1.30) to the 5th quintile group (HR: 1.47; 95% CI: 1.29-1.67) when compared to the 1st quintile group. We also found positive although non-linear associations between dietary exposure to PBDE and T2D risk, with an increased HR only for the 2nd and 4th vs. 1st quintile groups (HR: 1.12; 95% CI: 1.02-1.24, and HR: 1.20; 95% CI: 1.08-1.34, respectively). CONCLUSION: The findings suggest an association between dietary exposure to BFRs and T2D risk, highlighting the importance of further investigating this association the long-term health effects of endocrine disruptors in the general population. Additional studies are needed to reproduce these findings in other populations and clarify the underlying biological mechanisms.
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Authors | Jeanne Sandrine Ongono, Courtney Dow, Juliette Gambaretti, Gianluca Severi, Marie-Christine Boutron-Ruault, Fabrice Bonnet, Guy Fagherazzi, Francesca Romana Mancini |
Journal | Environment international
(Environ Int)
Vol. 123
Pg. 54-60
(02 2019)
ISSN: 1873-6750 [Electronic] Netherlands |
PMID | 30496982
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
- Endocrine Disruptors
- Flame Retardants
- Halogenated Diphenyl Ethers
- Hydrocarbons, Brominated
- hexabromocyclododecane
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Topics |
- Cohort Studies
- Diabetes Mellitus, Type 2
(chemically induced)
- Dietary Exposure
(analysis)
- Endocrine Disruptors
(adverse effects, analysis)
- Female
- Flame Retardants
(adverse effects, analysis)
- Halogenated Diphenyl Ethers
(adverse effects, analysis)
- Humans
- Hydrocarbons, Brominated
(adverse effects, analysis)
- Middle Aged
- Risk Factors
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