Comparison of the use of antibiotic-loaded calcium sulphate and wound irrigation-suction in the treatment of lower limb chronic osteomyelitis.

Abstract

AIMS:

We sought to compare the efficacy of antibiotic-loaded calcium sulphate with wound irrigation-suction in patients with lower limb chronic osteomyelitis.

PATIENTS AND METHODS:

Adult patients with lower limb chronic osteomyelitis treated at our hospital by means of segmental bone resection, antibiotic-loaded calcium sulphate implantation or wound irrigation-suction, followed by bone transport with external fixator from January 2011 to July 2015 were retrospectively evaluated. The clinical presentation, laboratory results, complications, docking obstruction, infection recurrence were compared.

RESULTS:

There were totally 74 patients met the inclusion criteria. Docking obstruction rate and infection recurrence were higher in the irrigation group with significant difference. The success rate of the first operation was 90.74% in the calcium sulphate group compared with 45% in the irrigation group. Postoperaton leakage of the incision happened more in the calcium sulphate group, but it wasn't a risk factor for docking obstruction and infection recurrence. Patients in the calcium sulphate group had shorter hospital stay and systemic antibiotic treatment, also with less external fixator index.

CONCLUSIONS:

The findings of our study suggest that antibiotic-loaded calcium sulphate implantation for lower chronic limb osteomyelitis was a more successful method than wound irrigation-suction, it greatly decreased infection recurrence and docking obstruction. Postoperative leakage after implantation didn't worsen patient's outcome.

• Authors: Cheng-He Qin, Hong-An Zhang, Yu-Han Chee, Astuti Pitarini, Abdulnassir Adem Ali
• Journal: Injury (Injury) Vol. 50 Issue 2 Pg. 508-514 (Feb 2019) ISSN: 1879-0267 [Electronic] Netherlands
• PMID: 30447985 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2018 Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Calcium Sulfate

Topics

• Adult
• Anti-Bacterial Agents (administration & dosage, pharmacology)
• Calcium Sulfate (administration & dosage, pharmacology)
• Chronic Disease (therapy)
• Cohort Studies
• Debridement
• Drug Delivery Systems
• Female
• Humans
• Lower Extremity (pathology)
• Male
• Osteomyelitis (pathology, therapy)
• Suction (methods)
• Therapeutic Irrigation (methods)
• Treatment Outcome
• Wound Healing (physiology)