Abstract |
The aim of this study was to analyze the efficacy of using rhBMP-2 (recombinant human morphogenetic protein-2) in the treatment of patients with cleft lip and palate defects (CLPD). Seven databases were screened: PubMed (Medline), Lilacs, Ibecs, Web of Science, BBO, Scopus, and The Cochrane Library. Clinical trials that evaluated the use of bioactive treatment with rhBMP-2 in the treatment of patients with CLPD were included. Statistical analyses were performed by comparing the standardized mean difference of bone formation volume and bone filling percentage (p = 0.05). Ten studies compared the use of rhBMP-2 and iliac crest bone graft (ICBG). The global analysis for bone formation volume and bone filling percentage showed that bioactive materials were similar to ICBG with a standardized mean difference of respectively 0.07 (95% CI - 0.41 to 0.56) and 0.24 (95% CI - 0.32 to 0.80). The available literature suggested that use of rhBMP-2 presented similar bone formation results to those of ICBG in secondary alveolar bone grafting for patients with CLPD.
|
Authors | Wellington Luiz de Oliveira da Rosa, Tiago Machado da Silva, Arthur Dias Galarça, Evandro Piva, Adriana Fernandes da Silva |
Journal | Calcified tissue international
(Calcif Tissue Int)
Vol. 104
Issue 2
Pg. 115-129
(02 2019)
ISSN: 1432-0827 [Electronic] United States |
PMID | 30367200
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review)
|
Chemical References |
- Bone Morphogenetic Protein 2
- Recombinant Proteins
- Transforming Growth Factor beta
- recombinant human bone morphogenetic protein-2
|
Topics |
- Bone Morphogenetic Protein 2
(therapeutic use)
- Bone Transplantation
(methods)
- Cleft Lip
(drug therapy, epidemiology)
- Cleft Palate
(drug therapy, epidemiology)
- Humans
- Maxillofacial Abnormalities
(drug therapy, epidemiology)
- Palate
(drug effects, embryology, physiology)
- Recombinant Proteins
(therapeutic use)
- Transforming Growth Factor beta
(therapeutic use)
- Treatment Outcome
|