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Efficacy of rhBMP-2 in Cleft Lip and Palate Defects: Systematic Review and Meta-analysis.

Abstract
The aim of this study was to analyze the efficacy of using rhBMP-2 (recombinant human morphogenetic protein-2) in the treatment of patients with cleft lip and palate defects (CLPD). Seven databases were screened: PubMed (Medline), Lilacs, Ibecs, Web of Science, BBO, Scopus, and The Cochrane Library. Clinical trials that evaluated the use of bioactive treatment with rhBMP-2 in the treatment of patients with CLPD were included. Statistical analyses were performed by comparing the standardized mean difference of bone formation volume and bone filling percentage (p = 0.05). Ten studies compared the use of rhBMP-2 and iliac crest bone graft (ICBG). The global analysis for bone formation volume and bone filling percentage showed that bioactive materials were similar to ICBG with a standardized mean difference of respectively 0.07 (95% CI - 0.41 to 0.56) and 0.24 (95% CI - 0.32 to 0.80). The available literature suggested that use of rhBMP-2 presented similar bone formation results to those of ICBG in secondary alveolar bone grafting for patients with CLPD.
AuthorsWellington Luiz de Oliveira da Rosa, Tiago Machado da Silva, Arthur Dias Galarça, Evandro Piva, Adriana Fernandes da Silva
JournalCalcified tissue international (Calcif Tissue Int) Vol. 104 Issue 2 Pg. 115-129 (02 2019) ISSN: 1432-0827 [Electronic] United States
PMID30367200 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review)
Chemical References
  • Bone Morphogenetic Protein 2
  • Recombinant Proteins
  • Transforming Growth Factor beta
  • recombinant human bone morphogenetic protein-2
Topics
  • Bone Morphogenetic Protein 2 (therapeutic use)
  • Bone Transplantation (methods)
  • Cleft Lip (drug therapy, epidemiology)
  • Cleft Palate (drug therapy, epidemiology)
  • Humans
  • Maxillofacial Abnormalities (drug therapy, epidemiology)
  • Palate (drug effects, embryology, physiology)
  • Recombinant Proteins (therapeutic use)
  • Transforming Growth Factor beta (therapeutic use)
  • Treatment Outcome

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