Nanoparticles for postinfarct ventricular remodeling.

Abstract

In recent years, tremendous progress has been made in the treatment of acute myocardial infarction, but pathological ventricular remodeling often causes survivors to suffer from fatal heart failure. Currently, there is no effective therapy to attenuate ventricular remodeling. Recently, nanoparticle-based drug delivery systems are widely applied in biomedicine especially in cancer and liver fibrosis, owing to its excellent physical, chemical and biological properties. Therefore, the use of nanoparticles as delivery vehicles of small molecules, polypeptides, etc. to improve postinfarct ventricular remodeling is expected. In this review, we summarize the updated researches in this fast-growing area and suggest further works needed.

• Authors: Caijuan Dong, Aiqun Ma, Lijun Shang
• Journal: Nanomedicine (London, England) (Nanomedicine (Lond)) Vol. 13 Issue 23 Pg. 3037-3050 (12 2018) ISSN: 1748-6963 [Electronic] England
• PMID: 30354963 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers
• Drug Carriers
• Peptides

Topics

• Animals
• Biomarkers (metabolism)
• Drug Carriers (chemistry)
• Drug Liberation
• Heart Failure (diagnosis, drug therapy)
• Humans
• Myocardial Infarction (diagnosis, drug therapy)
• Nanoparticles (chemistry, therapeutic use)
• Peptides (pharmacology)
• Signal Transduction
• Ventricular Remodeling (drug effects)