Hepatic Arterial Infusion Chemotherapy Is a Feasible Treatment Option for Breast Cancer with Liver-predominant Metastatic Disease.

Abstract

BACKGROUND:

Patients with liver metastasis from breast cancer (LMBC) are usually offered systemic therapy. However, for those with progressive liver disease and limited extra-hepatic conditions, local liver management becomes an option. Herein we present our experience with hepatic arterial infusion chemotherapy (HAIC).

PATIENTS AND METHODS:

From 1999 to 2018, 42 patients with LMBC, who had progressive liver metastasis after systemic therapy, were treated with HAIC. A catheter was placed angiographically into the hepatic artery and remained there for 5 consecutive days. One cycle of chemotherapy consisted of mitoxantrone, 5-fluorouracil, folinic acid, and cisplatin. This treatment was repeated at monthly intervals. The medical records were reviewed and analyzed for hepatic tumor response, progression-free survival, overall survival and adverse effects.

RESULTS:

Complete response was observed in two patients (5%), partial response in 18 patients (43%) and stable disease in eight patients (19%). Fourteen patients (33%) had progressive disease after HAIC. The median progression-free survival and overall survival were 8.4 and 19.3 months, respectively. There was no death related to HAIC. The patients with response to the treatment had a significant survival benefit (p<0.005).

CONCLUSION:

HAIC can be an option for those with progressive liver disease who are heavily pretreated while their extra-hepatic conditions are minimal or stable.

• Authors: Jui-Hu Hsiao, Hong-Tai Chang, Yen-Dun Tseng, Chia-Ling Chiang, I-Shu Chen, Yu-Chia Chen, Po-Ming Chang, Being-Whey Wang
• Journal: In vivo (Athens, Greece) (In Vivo) 2018 Nov-Dec Vol. 32 Issue 6 Pg. 1635-1641 ISSN: 1791-7549 [Electronic] Greece
• PMID: 30348727 (Publication Type: Journal Article)
• Copyright: Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Cisplatin

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Breast Neoplasms (drug therapy, pathology)
• Cisplatin (administration & dosage)
• Female
• Hepatic Artery (drug effects)
• Humans
• Liver (drug effects, pathology)
• Liver Neoplasms (drug therapy, pathology)
• Middle Aged
• Neoplasm Metastasis
• Treatment Outcome