Enhanced response of tamoxifen toward the cancer cells using a combination of chemotherapy and photothermal ablation induced by lentinan-functionalized multi-walled carbon nanotubes.

Abstract

A lentinan (LEN) functionalized multi-walled carbon nanotubes (MWCNTs) drug delivery system, using tamoxifen (TAM) as a model anticancer agent, was developed by a simple non-covalent approach. This developed system (MWCNTs-TAM-LEN) possessed good stability, water dispersibility and extraordinary photothermal properties. It was demonstrated by the in vitro experiments that MWCNTs-TAM-LEN had enhanced cellular uptake, antitumor activity and cell apoptosis on Mcf-7 cells in comparison with TAM and MWCNTs-TAM. The cell inhibition rate and apoptosis rate of Mcf-7 cells treated by MWCNTs-TAM-LEN with near-infrared (NIR) were 67.1% and 66.5% higher than that of equivalent concentration of TAM with NIR irradiation treatment, respectively. The enhanced antitumor efficacy of MWCNTs-TAM-LEN was realized via the synergistic function of chemotherapy and photothermal ablation under NIR laser irradiation.

• Authors: Wenhui Yi, Ping Zhang, Jin Hou, Weiping Chen, Lei Bai, Sweejiang Yoo, Asif Khalid, Xun Hou
• Journal: International journal of biological macromolecules (Int J Biol Macromol) Vol. 120 Issue Pt B Pg. 1525-1532 (Dec 2018) ISSN: 1879-0003 [Electronic] Netherlands
• PMID: 30227209 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Drug Carriers
• Nanotubes, Carbon
• Tamoxifen
• Lentinan

Topics

• Ablation Techniques
• Biological Transport
• Combined Modality Therapy
• Drug Carriers (chemistry)
• Humans
• Lentinan (chemistry)
• MCF-7 Cells
• Models, Molecular
• Molecular Conformation
• Nanotubes, Carbon (chemistry)
• Tamoxifen (chemistry, metabolism, pharmacology, therapeutic use)