The expression and correlation between chemokine CCL7 and ABCE1 in non-small cell lung cancer.

Abstract

Lung cancer is a malignant disease, and has the highest incidence and mortality worldwide. Lung cancer is also a popular subject in the field of cancer research. The molecular mechanisms of lung cancer development, invasion and metastasis need to be determined to prolong survival times and improve the quality of life. Recent studies have demonstrated that ATP-binding cassette sub-family E member 1 (ABCE1) is one of the factors that contributes to the development and metastasis of lung cancer, but the specific mechanism of this phenomenon remains unclear. A polymerase chain reaction microarray was used in the present study to screen for chemokine (C-C motif) ligand 7 (CCL7) expression in cell lines that highly expressed ABCE1, and the results showed that CCL7 was highly expressed in H1299 cells (P<0.01). The expression of CCL7 and ABCE1 in lung cancer tissues obtained from 30 patients with non-small cell lung cancer (NSCLC) was higher than that in adjacent normal lung tissues (P<0.01), and a positive correlation between the expression levels of the two genes in NSCLC was observed. These findings indicate that ABCE1 is involved in the development and progression of lung cancer through the CCL7 signaling pathway.

• Authors: Zhuo Wu, Ye Tian, Qian Yu, Hongyuan Li, Zhiqiang Tian, Hongfang Jiang, Dali Tian, Xueying Yang
• Journal: Experimental and therapeutic medicine (Exp Ther Med) Vol. 16 Issue 4 Pg. 3004-3010 (Oct 2018) ISSN: 1792-0981 [Print] Greece
• PMID: 30214518 (Publication Type: Journal Article)