Liposomal nanocarriers for statins: A pharmacokinetic and pharmacodynamics appraisal.

Abstract

Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, are a well-known class of drug with beneficial therapeutic effects in cardiovascular disease and lipid disorders and have potential use against cancer. However, the bioavailability of statins is hampered due to low aqueous solubility and rapid metabolism. To improve pharmacokinetic profiles of statins, development of drug delivery systems is promising. Hence, the use of liposomes for selective delivery of statins to a selected site or for bioavailability enhancement is an effective strategy to increase statin therapeutic effects. Moreover, liposomal delivery can reduce the required dose of statins especially in terms of antitumor effects. Liposomes, because of their unique properties and biphasic and amphiphilic nature, have attracted much interest and can be considered as a suitable choice for delivery of both hydrophilic and lipophilic statins. In this review article, we focus on liposomes and evaluate the effects of different liposomal delivery systems, based on differences in size, phospholipid composition, circulation half-life, and cholesterol content, on statin function.

• Authors: Anis Askarizadeh, Alexandra E Butler, Ali Badiee, Amirhossein Sahebkar
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 234 Issue 2 Pg. 1219-1229 (02 2019) ISSN: 1097-4652 [Electronic] United States
• PMID: 30203471 (Publication Type: Journal Article, Review)
• Copyright: © 2018 Wiley Periodicals, Inc.

Chemical References

• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Lipids
• Liposomes

Topics

• Administration, Oral
• Animals
• Biological Availability
• Drug Compounding
• Dyslipidemias (blood, diagnosis, drug therapy)
• Half-Life
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (administration & dosage, chemistry, pharmacokinetics)
• Lipids (chemistry)
• Liposomes
• Nanomedicine
• Nanoparticles
• Solubility
• Treatment Outcome