Ceftobiprole is a novel broad-spectrum
cephalosporin with excellent activity against a broad range of pathogens that are important in community-acquired
pneumonia (CAP), including
drug-resistant pneumococci, methicillin-resistant Staphylococcus aureus, and Pseudomonas aeruginosa. Areas covered: This article reviews the spectrum of activity, the main pharmacological and pharmacodynamic characteristics of
ceftobiprole as well its clinical efficacy and safety in the treatment of CAP in adult patients. Expert opinion: Taking into account that the current treatment guidelines for CAP recommend the use of an adequate empirical
therapy to improve its prognosis,
ceftobiprole shows a profile of antimicrobial activity that would cover most etiological agents in patients with risk factors for
infection caused by multidrug resistant organisms. The results of the pivotal clinical trial of patients hospitalized with CAP treated with
ceftobiprole showed a high rate of clinical cure. The clinical tolerance of
ceftobiprole in clinical trials was generally very good. These findings make
ceftobiprole a good parenteral therapeutic alternative for the empirical treatment of CAP that requires hospitalization, especially in patients with risk factors for CAP caused by resistant microorganisms.