Abstract | OBJECTIVE: METHODS: We recruited 130 children-65 with persistent allergic rhinitis and 65 healthy controls. A cross-sectional study was performed to compare endothelial function by flow-mediated dilation, blood levels of isoprostanes, serum activity of soluble NOX2-dp (sNOX2-dp), and nitric oxide bioavailability, in these 2 groups of children. Serum cotinine levels were assessed to measure exposure to passive smoking. RESULTS: Compared with healthy controls, children with persistent allergic rhinitis had significantly higher sNOX2-dp and isoprostanes levels, lower flow-mediated dilation, and reduced nitric oxide bioavailability. Multivariable linear regression analysis showed that flow-mediated dilation, isoprostanes, and cotinine were independently associated with sNOX2-dp levels. Of note, sNOX2-dp serum levels were significantly higher in children with allergic rhinitis exposed to smoke, as compared with unexposed children with allergic rhinitis. CONCLUSION: NOX2 is activated in children with persistent allergic rhinitis and passive smoke exposure exacerbates this effect. We further demonstrate an association between higher sNOX2-dp and oxidative stress and endothelial dysfunction.
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Authors | Lorenzo Loffredo, Anna Maria Zicari, Francesca Occasi, Ludovica Perri, Roberto Carnevale, Simona Battaglia, Francesco Angelico, Maria Del Ben, Francesco Martino, Cristina Nocella, Alessio Farcomeni, Giovanna De Castro, Marzia Duse, Francesco Violi |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 202
Pg. 252-257
(11 2018)
ISSN: 1097-6833 [Electronic] United States |
PMID | 30172425
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Tobacco Smoke Pollution
- Nitric Oxide
- NADPH Oxidase 2
- Cotinine
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Topics |
- Adult
- Age Factors
- Arterial Occlusive Diseases
(blood, physiopathology)
- Biomarkers
(blood)
- Cardiovascular Diseases
(etiology, prevention & control)
- Child
- Cotinine
(blood)
- Cross-Sectional Studies
- Disease Progression
- Endothelium, Vascular
(pathology, physiopathology)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Italy
- Linear Models
- Male
- Multivariate Analysis
- NADPH Oxidase 2
(blood)
- Nitric Oxide
(blood)
- Oxidative Stress
(physiology)
- Prognosis
- Reference Values
- Retrospective Studies
- Rhinitis, Allergic
(blood, physiopathology)
- Risk Assessment
- Sex Factors
- Tobacco Smoke Pollution
(adverse effects)
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