[Huanshao Capsules combined with levocarnitine for the treatment of asthenospermia, oligospermia and teratozoospermia].

Abstract

OBJECTIVE:

To observe the clinical effects of Huanshao Capsules (HSC) combined with levocarnitine (LC) on asthenospermia, oligospermia, teratozoospermia, and the semen parameters of the patients.

METHODS:

This randomized controlled clinical study included 186 infertility patients with spleen and kidney asthenia. We randomly divided them into three groups of equal number and treated them orally with HSC at the dose of 3 capsules tid, LC at 10 ml tid, and HSC+LC, respectively, all for 12 weeks. At 4, 8, and 12 weeks after treatment, we obtained the semen parameters from the patients and compared them among the three groups.

RESULTS:

Totally, 180 of the patients completed the study, 61 in the HSC, 59 in the LC and 60 in the HSC+LC group. After 12 weeks of medication, the patients of the HSC+LC group showed an increase of 42.77% in the semen volume, 142.37% in sperm concentration, 28.61% in sperm motility, and 24.39% in the percentage of grade a+b sperm and a decrease of 6.27% in the percentage of morphologically abnormal sperm as compared with the baseline (P <0.05). The patients treated with HSC+LC showed significantly more improvement in all the above parameters than those treated with LC alone (P <0.05) as well as in sperm motility and the percentage of progressively motile sperm than those treated with HSC alone (P <0.05). The HSC group exhibited remarkable improvement in the above parameters after treatment as compared with the baseline (P <0.05) and higher semen volume and sperm concentration than the LC group (P <0.05).

CONCLUSIONS:

Huanshao Capsulescombined with levocarnitinedeserves a wide clinical application as a safe and efficacious therapy forasthenospermia, oligospermia,and teratozoospermia.

• Authors: He-Yun Zhang, Jian Li, Yun Zhao, Hong-Jing Zhang, Xiao-Fang Bi, Chun-Hui Wang, Yang Yang, Jie Xiong, Yun-Qiang Shi, Yi-Ming Zhong, Chun-He Zhang
• Journal: Zhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) 2018 Janurary Vol. 24 Issue 1 Pg. 67-71 ISSN: 1009-3591 [Print] China
• PMID: 30157364 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Capsules
• Drugs, Chinese Herbal
• Carnitine

Topics

• Administration, Oral
• Asthenozoospermia (drug therapy)
• Capsules
• Carnitine (therapeutic use)
• Drug Therapy, Combination
• Drugs, Chinese Herbal (therapeutic use)
• Humans
• Male
• Oligospermia (drug therapy)
• Semen (drug effects)
• Semen Analysis
• Sperm Count
• Sperm Motility
• Teratozoospermia (drug therapy)