Abstract | PURPOSE: Poliovirus has been nearly eliminated as part of a world-wide effort to immunize and contain circulating wild-type polio. Nevertheless, poliovirus has been detected in water supplies and represents a threat to patients with humoral immunodeficiencies where infection can be fatal. To define the risk, we analyzed antibodies to poliovirus 1, 2, and 3 in serum samples collected over a year from patients with primary immunodeficiency diseases (PID) on regular intravenous immunoglobulin ( IVIG) replacement. METHODS: RESULTS: All IVIG samples had detectable antibodies to the three poliovirus serotypes. Despite that, only 52.4, 61.9, and 19.0% of patients showed protective antibody titers for poliovirus 1, 2, and 3, respectively. Only two patients (9.5%) had protective antibodies for the three poliovirus serotypes on all samples. Most patients were therefore susceptible to all three poliovirus serotypes. CONCLUSIONS: This study demonstrates the need for ongoing vigilance regarding exposure of patients with PID to poliovirus in the community.
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Authors | Beatriz T Costa-Carvalho, Kathleen E Sullivan, Patrícia M Fontes, Fernanda Aimé-Nobre, Isabela G S Gonzales, Elaine S Lima, Celso Granato, Maria Isabel de Moraes-Pinto |
Journal | Journal of clinical immunology
(J Clin Immunol)
Vol. 38
Issue 5
Pg. 628-634
(07 2018)
ISSN: 1573-2592 [Electronic] Netherlands |
PMID | 30006913
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Neutralizing
- Antibodies, Viral
- Immunoglobulins, Intravenous
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Topics |
- Adolescent
- Adult
- Antibodies, Neutralizing
(blood, immunology)
- Antibodies, Viral
(blood, immunology)
- Child
- Child, Preschool
- Female
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Immunologic Deficiency Syndromes
(blood, diagnosis, drug therapy, immunology)
- Male
- Middle Aged
- Poliovirus
(classification, immunology)
- Prospective Studies
- Serogroup
- Treatment Outcome
- Young Adult
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