Abstract | BACKGROUND: OBJECTIVES: METHODS: Fasting plasma RLP-C and LDL-TG levels were measured in 9,334 men and women without prevalent CVD. Participants were followed for incident CVD events ( coronary heart disease and ischemic stroke) for up to 16 years. Associations between LDL-TG and RLP-C levels and genetic variants were assessed by whole-exome sequencing using single-variant analysis for common variants and gene-based burden tests for rare variants; both an unbiased and a candidate gene approach were explored. RESULTS: RLP-C and LDL-TG levels were correlated with triglyceride levels (r = 0.85 and r = 0.64, p < 0.0001). In minimally adjusted analyses, RLP-C and LDL-TG were associated with CVD risk, but in models adjusted for traditional risk factors including lipids, only LDL-TG was associated with incident CHD (hazard ratio: 1.28; 95% confidence interval: 1.10 to 1.50) and stroke (hazard ratio: 1.47; 95% confidence interval: 1.13 to 1.92). A common APOE variant, rs7412, had the strongest association with LDL-TG and RLP-C (p < 5 × 10-8). CONCLUSIONS: RLP-C and LDL-TG levels were predictive of CVD and associated with APOE variants. LDL-TG may represent a marker of dysfunctional remnant lipoprotein metabolism associated with increased CVD risk. Further research is needed to determine whether LDL-TG plays a causal role in CVD and may be a target for therapy.
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Authors | Anum Saeed, Elena V Feofanova, Bing Yu, Wensheng Sun, Salim S Virani, Vijay Nambi, Josef Coresh, Cameron S Guild, Eric Boerwinkle, Christie M Ballantyne, Ron C Hoogeveen |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 72
Issue 2
Pg. 156-169
(07 10 2018)
ISSN: 1558-3597 [Electronic] United States |
PMID | 29976289
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- ApoE protein, human
- Apolipoproteins E
- Cholesterol, LDL
- Lipoproteins
- Triglycerides
- remnant-like particle cholesterol
- Cholesterol
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Topics |
- Aged
- Apolipoproteins E
(genetics)
- Cardiovascular Diseases
(blood, genetics)
- Cholesterol
(blood)
- Cholesterol, LDL
(chemistry)
- Exome
- Female
- Humans
- Lipoproteins
(blood)
- Male
- Middle Aged
- Prospective Studies
- Triglycerides
(blood)
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