Abstract |
Measurement of lung function can be difficult in young children. Structured light plethysmography (SLP) is a novel, noncontact method of measuring tidal breathing that monitors displacement of the thoraco-abdominal wall. SLP was used to compare breathing in children recovering from an acute exacerbation of asthma/wheeze and an age-matched cohort of controls. Children aged 2-12 years with acute asthma/wheeze (n = 39) underwent two 5-min SLP assessments, one before bronchodilator treatment and one after. SLP was performed once in controls (n = 54). Nonparametric comparisons of patients to healthy children and of pre- bronchodilator to post- bronchodilator were made for all children, and also stratified by age group (2-5 vs. 6-12 years old). In the asthma/wheeze group, IE50SLP (inspiratory to expiratory flow ratio) was higher (median 1.47 vs. 1.31; P = 0.002), thoraco-abdominal asynchrony (TAA) and left-right asynchrony were greater (both P < 0.001), and respiratory rate was faster (P < 0.001) than in controls. All other timing indices were shorter and displayed reduced variability (all P < 0.001). Variability in time to peak inspiratory flow was also reduced (P < 0.001). Younger children showed a greater effect than older children for TAA (interaction P < 0.05). After bronchodilator treatment, the overall cohort showed a reduction in within-subject variability in time to peak expiratory flow only (P < 0.001). Younger children exhibited a reduction in relative contribution of the thorax, TAA, and variability in TAA (interaction P < 0.05). SLP can be successfully performed in young children. The potential of SLP to monitor diseases such as asthma in children is worthy of further investigation. ClinicalTrials.gov identifier: NCT02543333.
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Authors | Hamzah Hmeidi, Shayan Motamedi-Fakhr, Edward K Chadwick, Francis J Gilchrist, Warren Lenney, Richard Iles, Rachel C Wilson, John Alexander |
Journal | Physiological reports
(Physiol Rep)
Vol. 6
Issue 12
Pg. e13752
(06 2018)
ISSN: 2051-817X [Electronic] United States |
PMID | 29932498
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. |
Chemical References |
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Topics |
- Acute Disease
- Age Distribution
- Age Factors
- Asthma
(drug therapy, physiopathology)
- Bronchodilator Agents
(pharmacology, therapeutic use)
- Case-Control Studies
- Child
- Child, Preschool
- Female
- Humans
- Male
- Plethysmography
(methods)
- Respiratory Function Tests
- Respiratory Rate
(drug effects)
- Tidal Volume
(drug effects, physiology)
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