[Efficacy and safety of mycophenolate mofetil in treating neuromyelitis optica spectrum disorder: a multicenter, prospective, self-control study in Guangzhou City].

Abstract

Objective: To evaluate the efficacy and safety of mycophenolate mofetil (MMF) in neuromyelitis optica spectrum disorder (NMOSD). Method: From September 2014 to February 2017, NMOSD patients with seropositive aquaporin4-IgG was enrolled through a multicenter, prospective study, and the annual recurrence rate (ARR), Expanded Disability Status Scale (EDSS) and MMF-related side effects before and after MMF treatment were compared. Results: Ninety patients were enrolled in the study. After being treated for a median of 12 months (1-30 months), the median ARR decreased from 1.1 pre-MMF to 0 post-MMF (P<0.001), and the median EDSS score decreased from 4.0 pre-MMF to 3.0 post-MMF (P<0.001). The EDSS score reduced significantly after 90 days' treatment (P<0.05). The main adverse events included the deranged liver enzymes (19%, 17/90), respiratory infection (11%, 10/90), urinary tract infection (6%, 5/90), varicella-zoster infection (6%, 5/90), anemia (6%, 5/90), leucopenia (6%, 5/90), diarrhea (2%, 2/90), hair loss (1%, 1/90); 11% (10/90) patients experienced severe adverse events, and 6% (5/90) patients discontinued MMF. Conclusions: MMF could significantly reduce the ARR and EDSS score of NMOSD. However, awareness on side effects should be raised.

• Authors: Q Huang, Y G Wang, Y Q Shu, H Yang, Z H Wang, Z W Yan, Y M Long, J Yin, H Y Feng, C X Li, Z Z Lu, X Q Hu, W Qiu
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 98 Issue 21 Pg. 1664-1668 (Jun 05 2018) ISSN: 0376-2491 [Print] China
• PMID: 29925143 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Immunosuppressive Agents
• Mycophenolic Acid

Topics

• Humans
• Immunosuppressive Agents
• Mycophenolic Acid
• Neuromyelitis Optica
• Prospective Studies
• Self-Control
• Treatment Outcome