[Activity of guanosine diphosphatase and guanosine triphosphatase in the rat brain and liver under radiation injury].

Abstract

The activity of guanosine diphosphatase (GDPase) and guanosine triphosphatase (GTPase) was determined in mitochondrial fractions and postmitochondrial supernatant fluid from the rat brain and liver nuclei 1, 3, 6, 24 and 48 hours after their irradiation by gamma-quanta of [60Co] in a dose of 774 mC/kg. Under the influence of irradiation the activity of GDPase in the liver and brain mitochondria increased, that of GTPase in the liver mitochondria underwent phase changes. The GDPase activity tended to increase in postmitochondrial supernatant fraction of the liver and brain; the GTPase activity was at first inhibited and then increased.

• Authors: Savitskiĭ
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1985 Mar-Apr Vol. 57 Issue 2 Pg. 73-6 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: Aktivnost' guanozindifosfatazy i guanozintrifosfatazy v golovnom mozru i pecheni krys pri luchevom porazhenii.
• PMID: 2988171 (Publication Type: English Abstract, Journal Article)

Chemical References

• GTP Phosphohydrolases
• Pyrophosphatases
• guanosine-diphosphatase

Topics

• Animals
• Brain (enzymology, radiation effects)
• Cell Nucleus (enzymology)
• Cytosol (enzymology)
• GTP Phosphohydrolases (metabolism)
• Gamma Rays
• Liver (enzymology, radiation effects)
• Mitochondria, Liver (enzymology)
• Pyrophosphatases (metabolism)
• Rats
• Time Factors