Abstract |
A hetero-binuclear Ir(iii)-Pt(ii) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.
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Authors | Cheng Ouyang , Lei Chen , Thomas W Rees , Yu Chen , Jiankang Liu , Liangnian Ji , Jiangang Long , Hui Chao |
Journal | Chemical communications (Cambridge, England)
(Chem Commun (Camb))
Vol. 54
Issue 49
Pg. 6268-6271
(Jun 14 2018)
ISSN: 1364-548X [Electronic] England |
PMID | 29850704
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Coordination Complexes
- Organoplatinum Compounds
- Iridium
- Cisplatin
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Topics |
- Antineoplastic Agents
(chemical synthesis, pharmacology)
- Cell Line, Tumor
- Cisplatin
(pharmacology)
- Coordination Complexes
(chemical synthesis, pharmacology)
- Drug Resistance, Neoplasm
(drug effects)
- Humans
- Iridium
(chemistry)
- Mitochondria
(metabolism)
- Necrosis
(chemically induced)
- Organoplatinum Compounds
(chemical synthesis, pharmacology)
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