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A mitochondria-targeting hetero-binuclear Ir(iii)-Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells.

Abstract
A hetero-binuclear Ir(iii)-Pt(ii) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.
AuthorsCheng Ouyang , Lei Chen , Thomas W Rees , Yu Chen , Jiankang Liu , Liangnian Ji , Jiangang Long , Hui Chao
JournalChemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 54 Issue 49 Pg. 6268-6271 (Jun 14 2018) ISSN: 1364-548X [Electronic] England
PMID29850704 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Coordination Complexes
  • Organoplatinum Compounds
  • Iridium
  • Cisplatin
Topics
  • Antineoplastic Agents (chemical synthesis, pharmacology)
  • Cell Line, Tumor
  • Cisplatin (pharmacology)
  • Coordination Complexes (chemical synthesis, pharmacology)
  • Drug Resistance, Neoplasm (drug effects)
  • Humans
  • Iridium (chemistry)
  • Mitochondria (metabolism)
  • Necrosis (chemically induced)
  • Organoplatinum Compounds (chemical synthesis, pharmacology)

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