[The exploration of VEGF-B methylation in the nasal polyp].

Abstract

Objective:The objective of this study is to investigate the methylation status of vascular endothelial cell growth factor B (VEGF-B) gene and to indentify the roles in pathogenesis,development and classification of nasal polyps.Method:The methylation status of VEGF-B gene of 28 nasal polyp tissues and 12 samples of inferior turbinate tissues were detected by methylationspecific-polymerase chain reaction (MS-PCR) and gene sequencing.Result:There was significant statistic diference between nasal polyp tissue group and control group (χ ²=4.096,P<0.05). The results of gene sequencing suggest that the VEGF-B gene promoter were hypomethylation status in the nasal polyps.Conclusion:Methylation status of VEGF-B promoter may play an important role in the pathogenetic mechanism of nasal polyps.

• Authors: H Y Tan, W L Bai, X W Wang, T T Xu
• Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 31 Issue 19 Pg. 1482-1484;1491 (Oct 05 2017) ISSN: 2096-7993 [Print] China
• PMID: 29798099 (Publication Type: Journal Article)
• Copyright: Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

Chemical References

• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factor B

Topics

• Case-Control Studies
• Humans
• Inflammation (metabolism)
• Methylation
• Nasal Polyps (metabolism, pathology)
• Polymerase Chain Reaction
• Turbinates (pathology)
• Vascular Endothelial Growth Factor A (biosynthesis, genetics)
• Vascular Endothelial Growth Factor B (biosynthesis, genetics)