Diclofenac Sodium 3% in Hyaluronic Acid 2.5% Gel Significantly Diminishes the Actinic Keratosis Area and Severity Index.

Abstract

BACKGROUND/AIMS:

Actinic keratosis area and severity index (AKASI) is a new assessment tool to quantify the severity of actinic damage on the head. Thus far, it has not been evaluated in monitoring the efficacy of field-directed topical treatments in actinic keratosis (AK) in routine clinical practice. Thus, the aim of this study was to determine treatment outcomes by using AKASI 3 months after the initiation of topical application of diclofenac sodium 3% in hyaluronic acid 2.5% gel (DFS) in patients with AKs on the head.

METHODS:

We performed a retrospective analysis of patients with AKs who had AKASI scores prior to and after treatment with DFS.

RESULTS:

Of the 24 patients included, 20 (83.3%) showed an improvement in AKASI, 2 (8.3%) a stable AKASI, and 2 (8.3%) a worsening of AKASI after a median (interquartile range) follow-up period of 91.5 days (89.8-104.3). The median AKASI reduction was 31.4% (16.7-59.1). The Wilcoxon test showed significant differences (p = 0.0008) between baseline and posttreatment AKASI values.

CONCLUSIONS:

AKASI is an easy-to-use quantitative tool for assessing the treatment outcome of field-directed therapies. Field-directed therapies of AK should no longer be monitored by assessments based on lesion counts alone.

• Authors: Lutz Schmitz, Girish Gupta, Marc Hanno Segert, Ricarda Kost, Julia Sternberg, Thilo Gambichler, Eggert Stockfleth, Thomas Dirschka
• Journal: Skin pharmacology and physiology (Skin Pharmacol Physiol) Vol. 31 Issue 4 Pg. 206-211 ( 2018) ISSN: 1660-5535 [Electronic] Switzerland
• PMID: 29791916 (Publication Type: Journal Article)
• Copyright: © 2018 S. Karger AG, Basel.

Chemical References

• Dermatologic Agents
• Gels
• Diclofenac
• Hyaluronic Acid

Topics

• Administration, Cutaneous
• Aged
• Aged, 80 and over
• Dermatologic Agents (administration & dosage, therapeutic use)
• Diclofenac (administration & dosage, therapeutic use)
• Female
• Follow-Up Studies
• Gels
• Humans
• Hyaluronic Acid (administration & dosage, therapeutic use)
• Keratosis, Actinic (drug therapy, pathology)
• Male
• Retrospective Studies
• Severity of Illness Index
• Statistics, Nonparametric
• Treatment Outcome