Comparison of hyperdry amniotic membrane transplantation and conjunctival autografting for primary pterygium.

Abstract

BACKGROUND:

The purpose of this study was to evaluate the safety and effectiveness of the hyperdry amniotic membrane transplantation compared with conjunctival autografting for the treatment of primary pterygium.

METHODS:

One hundred and forty-one eyes from 130 patients with primary pterygium were treated with excision followed by hyperdry amniotic membrane or conjunctival autografting after random selection. Seventy-nine eyes from 71 patients received hyperdry amniotic membrane transplantation (HD-AM group), and 62 eyes from 59 patients received conjunctival autografting (CG group). Patients were followed up at one week and one, three, six, and 12 months post-surgery. Recurrence rate, postoperative complications, and final follow-up patient visits were prospectively evaluated.

RESULTS:

The mean follow-up duration was 12.56 ± 4.35 months in the HD-AM group and 12.85 ± 3.90 months in the CG group. Recurrences were detected in four eyes (5.06%) in the HD-AM group and 13 eyes (20.97%) in the CG group. A statistically significant difference in frequency of recurrence between the two groups (P = 0.003) was observed. The cumulative non-recurrence rates at six and 12 months in all patients stratified by age and sex were not significantly different (P = 0.642 and P = 0.451, respectively, by log-rank test). Graft retraction and necrosis were not detected in the two groups during the follow-up period.

CONCLUSION:

Hyperdry amniotic membrane transplantation was effective in preventing pterygium recurrence when compared with conjunctival autografting and can be considered a preferable and safe grafting procedure for primary pterygium.

TRIAL REGISTRATION:

Current Controlled Trials ISRCTN16900270 , Retrospectively registered (Date of registration: 3 May 2018).

• Authors: Xin Pan, Daguang Zhang, Zhifang Jia, Zhehui Chen, Yuetian Su
• Journal: BMC ophthalmology (BMC Ophthalmol) Vol. 18 Issue 1 Pg. 119 (May 15 2018) ISSN: 1471-2415 [Electronic] England
• PMID: 29764389 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Amnion (transplantation)
• Conjunctiva (transplantation)
• Female
• Follow-Up Studies
• Graft Survival
• Humans
• Male
• Middle Aged
• Ophthalmologic Surgical Procedures (methods)
• Pterygium (surgery)
• Recurrence
• Retrospective Studies
• Transplantation, Autologous