Temporal Neuromodulation of Retinal Ganglion Cells by Low-Frequency Focused Ultrasound Stimulation.
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| Abstract |
Significant progress has been made recently in treating neurological blindness using implantable visual prostheses. However, implantable medical devices are highly invasive and subject to many safety, efficacy, and cost issues. The discovery that ultrasound (US) may be useful as a noninvasive neuromodulation tool has aroused great interest in the field of acoustic retinal prostheses (ARPs). We have investigated the responsiveness of rat retinal ganglion cells (RGCs) to low-frequency focused US stimulation (LFUS) at 2.25 MHz and characterized the neurophysiological properties of US responses by performing in vitro multielectrode array recordings. The results show that LFUS can reliably activate RGCs. The US-induced responses did not correspond to the standard light responses and varied greatly among cell types. Moreover, dual-peak responses to US stimulation were observed that have not been reported previously. The temporal response properties of RGCs, including their latency, firing rate, and response type, were modulated by the acoustic intensity. These findings suggest the presence of a temporal neuromodulation effect of LFUS and potentially open a new avenue in the development of ARP.
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| Authors | Qiuju Jiang, Guofeng Li, Huixia Zhao, Wenlong Sheng, Lan Yue, Min Su, Shijun Weng, Leanne Lai-Hang Chan, Qifa Zhou, Mark S Humayun, Weibao Qiu, Hairong Zheng |
| Journal | IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society (IEEE Trans Neural Syst Rehabil Eng) Vol. 26 Issue 5 Pg. 969-976 (05 2018) ISSN: 1558-0210 [Electronic] United States |
| PMID | 29752231 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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