Abstract | BACKGROUND: METHODS: Serum samples were taken for routine biochemical investigation from 32 patients with autoimmune hepatitis and from 40 healthy subjects. Class I and II of ADH and ALDH activity was measured by the spectrofluorometric method. For measurement of class III ADH and total ADH activity we employed the photometric methods. RESULTS: The activity of the class I ADH isoenzyme was significantly higher in the sera of patients with autoimmune hepatitis. The median activity of this isoenzyme in the patients group was approximately 63% (3.94 mU/L) higher than the control level (1.46 mU/L). For this reason, the total ADH activity was also significantly increased. The activities of other ADH isoenzymes and ALDH tested were unchanged. CONCLUSIONS:
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Authors | Wojciech Jelski, Blanka Wolszczak-Biedrzycka, Elzbieta Zasimowicz-Majewska, Karolina Orywal, Joanna Piechota, Tadeusz W Lapinski, Marzena Bednarczyk, Maciej Szmitkowski |
Journal | Clinical laboratory
(Clin Lab)
Vol. 64
Issue 4
Pg. 477-481
(Apr 01 2018)
ISSN: 1433-6510 [Print] Germany |
PMID | 29739065
(Publication Type: Journal Article)
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Chemical References |
- Isoenzymes
- Alcohol Dehydrogenase
- Aldehyde Dehydrogenase
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Topics |
- Adult
- Aged
- Alcohol Dehydrogenase
(blood, metabolism)
- Aldehyde Dehydrogenase
(blood, metabolism)
- Female
- Hepatitis, Autoimmune
(blood, enzymology)
- Humans
- Isoenzymes
(blood, metabolism)
- Liver
(enzymology, pathology)
- Male
- Middle Aged
- Oxidation-Reduction
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