Effects of Kanglaite Injection on Serum miRNA-21 in Patients with Advanced Lung Cancer.

Abstract

BACKGROUND Lung cancer is the most common type of cancer throughout the world, and the morbidity of lung cancer is continuously increasing. Patients with advanced lung cancer often cannot tolerate chemoradiotherapy. The decrease of the expression of miRNA-21 can be used as an indicator of the therapeutic effect of lung cancer. In this study, the effect of Kanglaite injection on serum miRNA-21 in patients with advanced lung cancer was investigated, providing reliable and important evidences. MATERIAL AND METHODS From March 2016 to March 2017, 120 patients with advanced lung cancer were examined; we collected detailed information and serum samples. The patients were treated by intravenous drip of Kanglaite, which was provided by Zhejiang Kanglaite Pharmaceutical Co., Ltd., China. We administered 200 ml intravenous drip once per day for a total of 21 days. Serum samples were collected from patients after treatments. In this study, 4 observation indexes were considered - KPS (Karnofsky performance score, KPS), body weight, adverse effects, and miRNA-21 level - evaluated before and after the Kanglaite treatment. RESULTS Among 120 patients with advanced lung cancer, the KPS of 75 patients (63.1%) was increased after the treatment, and body weight was increased by 55.9%. In addition, serum miRNA-21 level after the Kanglaite treatment was 2.45±0.15, which was significantly lower than before treatment (3.87±0.54), (P<0.05). CONCLUSIONS The effect of Kanglaite injection on serum miRNA-21 in patients with advanced lung cancer was shown to significantly reduce the expression of miRNA-21, providing objective evidence for the effect of Kanglaite injection in patients with advanced lung cancer.

• Authors: Yue Wu, Jianbin Zhang, Yupeng Hong, Xiao Wang
• Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 24 Pg. 2901-2906 (May 08 2018) ISSN: 1643-3750 [Electronic] United States
• PMID: 29735968 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• MIRN21 microRNA, human
• MicroRNAs
• kang-lai-te

Topics

• Adult
• Aged
• Body Weight (drug effects)
• Drugs, Chinese Herbal (administration & dosage, adverse effects, pharmacology, therapeutic use)
• Female
• Humans
• Injections, Intravenous
• Lung Neoplasms (blood, drug therapy, genetics)
• Male
• MicroRNAs (blood, genetics)
• Middle Aged