Optical Coherence Tomography Angiography versus Dye Angiography in Age-Related Macular Degeneration: Sensitivity and Specificity Analysis.

Abstract

INTRODUCTION:

Optical coherence tomography angiography (OCTA) could be a valid tool to detect choroidal neovascularization (CNV) in neovascular age-related macular degeneration (nAMD), allowing the analysis of the type, the morphology, and the extension of CNV in most of the cases.

PURPOSE:

To determine the sensitivity and specificity of OCTA in detecting CNV secondary to nAMD, compared to fluorescein angiography (FA) and indocyanine green angiography (ICGA).

METHODS:

Prospective observational study. Patients with suspected nAMD were recruited between May and December 2016. Patients underwent FA, ICGA, spectral domain OCT, and OCTA (AngioVue, Optovue, Inc.). Sensitivity and specificity of FA, with or without ICGA, were assessed and compared with OCTA.

RESULTS:

Seventy eyes of 70 consecutive patients were included: 32 eyes (45.7%) with type I CNV, 8 eyes (11.4%) with type II CNV, 4 eyes (5.7%) with type III CNV, 6 eyes (8.6%) with mixed type I and type II CNV, and 20 eyes (28.6%) with no CNV. Sensitivity of OCTA was 88% and specificity was 90%. Concordance between FA/ICGA and OCTA was very good (0,91; range 0,81-1,00).

CONCLUSIONS:

OCTA showed high sensitivity and specificity for detection of CNV. Concordance between OCTA and gold-standard dye-based techniques was excellent. OCTA may represent a first-line noninvasive method for the diagnosis of nAMD.

• Authors: Eleni Nikolopoulou, Massimo Lorusso, Luisa Micelli Ferrari, Maria Vittoria Cicinelli, Francesco Bandello, Giuseppe Querques, Tommaso Micelli Ferrari
• Journal: BioMed research international (Biomed Res Int) Vol. 2018 Pg. 6724818 ( 2018) ISSN: 2314-6141 [Electronic] United States
• PMID: 29707575 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Observational Study)

Chemical References

• Indocyanine Green
• Fluorescein

Topics

• Aged
• Aged, 80 and over
• Angiography (methods)
• Female
• Fluorescein (administration & dosage)
• Humans
• Indocyanine Green (administration & dosage)
• Macular Degeneration (diagnostic imaging)
• Male
• Middle Aged
• Prospective Studies
• Sensitivity and Specificity
• Tomography, Optical Coherence (methods)