[Effect of ulinastatin on myocardial injury in patients with acute severe carbon monoxide poisoning].

Abstract

Objective: To observe the effect of ulinastatin on myocardial injury in patients with acute severe carbon monoxide poisoning (ASCOP) . Methods: By using the prospective study method, 123 cases of ASCOP patients admitted to our hospital, were randomly divided into two groups. There were no significantly different between the two groups in the abnormal rates of ECG, brain natriuretic peptide (BNP) , troponin I (cTNI) , creatine phosphokinase (CK-MB) and creatine phosphokinase (CK) . The control group according to the patients need to be treated with hyperbaric oxygen and routine medical treatment; the observation group was treated with ulinastatin 100 thousand u intravenous injection based on routine treatment measures on Q8 h, the two groups were 7 d for the 1 course of treatment. Compared two groups of patients after 3 days, 7 days of electrocardiogram, brain natriuretic peptide (BNP) , troponin I (cTNI) , creatine kinase isoenzyme (CK-MB) , creatine kinase (CK) , the case fatality rate within 14 days, and the abnormality rate of BNP, cTNI, CK-MB and Ck. Results: the observation group for 3 days, 7 days, 14 days were abnormal, brain natriuretic peptide (BNP) , cardiac troponin I (cTNI) , creatine kinase isoenzyme (CK-MB) , creatine kinase (CK) the average results were significantly lower than those in the control group (P<0.05) ; The 14 d BNP in the observation group was significantly lower than the control group (P<0. 05) ; the case fatality rateof observation group was lower than the control group within 14 days (1.2% vs 3.3%) . Conclusion: Ulinastatin can significantly improve the ASCOP to reduce the damage to the heart, reduce the case fatality rateand improve the prognosis.

• Authors: P Wang, W Li, J L Yang, Y Wang, Q Liu, W Z Wang, H N Qi, J Li
• Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) Vol. 36 Issue 2 Pg. 154-156 (Feb 20 2018) ISSN: 1001-9391 [Print] China
• PMID: 29699021 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Biomarkers
• Glycoproteins
• Troponin I
• Natriuretic Peptide, Brain
• Creatine Kinase
• Creatine Kinase, MB Form
• urinastatin

Topics

• Acute Disease
• Biomarkers
• Carbon Monoxide Poisoning (complications)
• Creatine Kinase (blood)
• Creatine Kinase, MB Form (blood)
• Electrocardiography
• Glycoproteins (pharmacology, therapeutic use)
• Heart Injuries (drug therapy)
• Humans
• Natriuretic Peptide, Brain (blood)
• Prospective Studies
• Treatment Outcome
• Troponin I (blood)