Objective: To study the relationship of serum
lipoprotein-associated phospholipase A2 (Lp-PLA2) with
vascular dementia (VD) after
ischemic stroke. Methods: A total of 226
ischemic stroke patients who visited the People's Hospital of Zhengzhou University from June.2013 to Oct.2016 were included and divided into the VD group and the non-
dementia group according to the degree of
cognitive impairment.The non-
dementia group were further divided into the normal cognition group and the vascular
cognitive impairment no
dementia(VCIND) group.The general information of all patients were collected and the serum
Lp-PLA2, Hcy,
hs-CRP and the blood
lipid indexes were detected.The Logistic regression model was built to analyze the association of
Lp-PLA2 with the VD, correlation analysis and ROC curve were conducted to analyze the correlation of
Lp-PLA2 with the state of
cognitive impairment and to generate the cutoff value respectively. Results: The serum
Lp-PLA2 in VD group[(221±84) ng/ml] was significant higher than the non-
dementia group[(133±60) ng/ml], the
Lp-PLA2 in VCIND group[(148±65) ng/ml] was significant higher than the normal cognition group[(114±48) ng/ml](P<0.05). The result of Logistic regression showed that
Lp-PLA2 was a significant risk factor of VD[(OR(95%CI)=1.015(1.010-1.021)], and its level was negatively correlated with the score of cognitive function.The cutoff value of
Lp-PLA2 between the VD and non-
dementia was 164.65 ng/ml and was 120.8 ng/ml between the normal cognition group and VCIND group. Conclusion:
Lp-PLA2 is a significant risk factor of VD after
ischemic stroke.