Role of metabolism in cancer cell radioresistance and radiosensitization methods.

Abstract

BACKGROUND:

Radioresistance is a major factor leading to the failure of radiotherapy and poor prognosis in tumor patients. Following the application of radiotherapy, the activity of various metabolic pathways considerably changes, which may result in the development of resistance to radiation.

MAIN BODY:

Here, we discussed the relationships between radioresistance and mitochondrial and glucose metabolic pathways, aiming to elucidate the interplay between the tumor cell metabolism and radiotherapy resistance. In this review, we additionally summarized the potential therapeutic targets in the metabolic pathways.

SHORT CONCLUSION:

The aim of this review was to provide a theoretical basis and relevant references, which may lead to the improvement of the sensitivity of radiotherapy and prolong the survival of cancer patients.

• Authors: Le Tang, Fang Wei, Yingfen Wu, Yi He, Lei Shi, Fang Xiong, Zhaojian Gong, Can Guo, Xiayu Li, Hao Deng, Ke Cao, Ming Zhou, Bo Xiang, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng
• Journal: Journal of experimental & clinical cancer research : CR (J Exp Clin Cancer Res) Vol. 37 Issue 1 Pg. 87 (Apr 23 2018) ISSN: 1756-9966 [Electronic] England
• PMID: 29688867 (Publication Type: Journal Article, Review)

Chemical References

• Radiation-Sensitizing Agents

Topics

• Humans
• Neoplasms (pathology, radiotherapy)
• Radiation Tolerance (immunology)
• Radiation-Sensitizing Agents (pharmacology, therapeutic use)