Abstract |
Previous studies have indicated that reactive oxygen species produced by NADPH oxidase (Nox) are important risk factors of hypertension. The current study aims to examine the associations of Nox-related genes with longitudinal blood pressure (BP) changes and the risk of incident hypertension in the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) follow-up study. A total of 1,768 participants from 633 families were included in our analysis. Nine BP measurements were obtained in the morning at baseline and during two follow-up visits. The mixed-effect models were used to investigate the associations of 52 tagged single-nucleotide polymorphisms in 11 Nox-related genes with BP changes and incident hypertension. Gene-based analyses were performed by truncated product method (TPM) and Versatile Gene-based Association Study (VEGAS). Over the 7.2 years of follow-up, systolic BP (SBP) and diastolic BP (DBP) increased, and 32.1% (512) of participants developed hypertension. SNPs rs12094228, rs16861188 and rs12066019 in NCF2 were significantly associated with longitudinal change in SBP (Pinteraction = 1.1 × 10-3, 2.8 × 10-3 and 1.2 × 10-3, respectively). Gene-based analyses revealed that NCF2 was significantly associated with SBP (PTPM = 1.00 × 10-6, PVEGAS = 1.26 × 10-4) and DBP changes (PTPM = 5.84 × 10-4, PVEGAS = 1.04 × 10-3). These findings suggested that NCF2 may play an important role in BP changes over time in the Han Chinese population.
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Authors | Hongfan Li, Xikun Han, Zunsong Hu, Jianfeng Huang, Jing Chen, James E Hixson, Dabeeru C Rao, Jiang He, Dongfeng Gu, Shufeng Chen |
Journal | Journal of human hypertension
(J Hum Hypertens)
Vol. 32
Issue 4
Pg. 287-293
(04 2018)
ISSN: 1476-5527 [Electronic] England |
PMID | 29463833
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Blood Pressure
(genetics)
- China
(epidemiology)
- Female
- Follow-Up Studies
- Humans
- Hypertension
(enzymology, epidemiology, genetics)
- Male
- Middle Aged
- NADPH Oxidases
(genetics)
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