Family history of cancer in first-degree relatives and risk of gastric cancer and its precursors in a Western population.

Abstract

BACKGROUND:

Family history may inform risks of gastric cancer and preneoplastic lesions.

METHODS:

We examined associations with history of cancer in first-degree relatives for 307 incident gastric cancer cases among 20,720 male smokers in a prospective study in Finland. Cox regression was used to calculate gastric cancer hazard ratios (HR) and 95% confidence intervals (95% CI). Logistic regression was used to estimate odds ratios (OR) and 95% CIs for low serum pepsinogen, a marker of gastric atrophy.

RESULTS:

Gastric cancer risk was associated with gastric cancer history in first-degree relatives overall (HR 1.56, 95% CI 1.15-2.12), in fathers (HR 1.67, 95% CI 1.09-2.55) and in siblings (HR 2.05, 95% CI 1.25-3.38). Associations were significant for noncardia (HR 1.83, 95% CI 1.30-2.57) but not cardia (HR 0.93, 95% CI 0.46-1.87) cancers, and marginal for both intestinal-(HR 1.53, 95% CI 0.92-2.55) and diffuse-type (HR 1.47, 95% CI 0.72-3.03) histologies. Family history of other cancer types was not associated with gastric cancer risk. Family history of gastric cancer was associated with low pepsinogen (OR 1.29, 95% CI 1.11-1.50).

CONCLUSIONS:

Family history of gastric cancer is strongly associated with specific subtypes of gastric cancer as well as with gastric atrophy, a risk factor for developing this malignancy.

• Authors: Minkyo Song, M Constanza Camargo, Stephanie J Weinstein, Ana F Best, Satu Männistö, Demetrius Albanes, Charles S Rabkin
• Journal: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (Gastric Cancer) Vol. 21 Issue 5 Pg. 729-737 (09 2018) ISSN: 1436-3305 [Electronic] Japan
• PMID: 29455268 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)

Chemical References

• Pepsinogen A

Topics

• Aged
• Aged, 80 and over
• Atrophy (blood)
• Finland
• Gastric Mucosa (pathology)
• Genetic Predisposition to Disease
• Helicobacter Infections (complications)
• Humans
• Logistic Models
• Male
• Medical History Taking
• Middle Aged
• Pedigree
• Pepsinogen A (blood)
• Stomach Neoplasms (genetics, pathology)